【摘要】： 目的研究經(jīng)皮、經(jīng)腔技術(shù)建立豬卵圓孔未閉模型的可行性,并利用該模型動(dòng)物研究Valsalva動(dòng)作與矛盾栓塞的關(guān)系。方法經(jīng)皮、經(jīng)腔穿刺和擴(kuò)張中華小型豬房間隔卵圓窩(預(yù)實(shí)驗(yàn)1只,實(shí)驗(yàn)組10只)。在靜脈注射栓塞物時(shí),實(shí)驗(yàn)組的5只豬(組1)有Valsalva動(dòng)作模擬,另5只(組2)則無。隨后進(jìn)行了影像學(xué)和病理學(xué)研究。結(jié)果11只豬的卵圓孔未閉模型均被成功建立。在注射栓塞物期間,盡管組1無1例發(fā)生房水平的平均壓力梯度翻轉(zhuǎn),但4例發(fā)生了房水平瞬間壓力梯度翻轉(zhuǎn),其中2例發(fā)生了MRI和病理證實(shí)的矛盾栓塞。組2則無1例發(fā)生房水平瞬間壓力梯度翻轉(zhuǎn)和矛盾栓塞。結(jié)論經(jīng)皮、經(jīng)腔技術(shù)建立豬卵圓孔未閉模型是可行的。通過房水平瞬間壓力梯度翻轉(zhuǎn)機(jī)制,Valsalva動(dòng)作與矛盾栓塞有關(guān)聯(lián)。
[Abstract]:Objective to study the feasibility of establishing porcine oval foramen patent model by percutaneous and transluminal technique, and to study the relationship between Valsalva movement and contradictory embolization. Methods Percutaneous, transluminal puncture and expansion of the Chinese miniature pig atrial septal oval fossa (pretest 1, experimental group 10). At the time of intravenous embolization, 5 pigs in the experimental group (group 1) had Valsalva motility simulation, while the other 5 pigs (group 2) had no action simulation. Imaging and pathological studies were followed. Results all the models of unclosed foramen ovale in 11 pigs were successfully established. During the injection of embolization, although none of the patients in group 1 had the mean pressure gradient reversal at the atrial level, 4 patients had transient pressure gradient reversal at the atrial level, and 2 of them had contradictory embolism confirmed by MRI and pathology. In group 2, there was no transient pressure gradient reversal and contradictory embolization. Conclusion it is feasible to establish porcine oval foramen patent model by percutaneous and transluminal technique. Valsalva action was associated with contradictory embolism through the transient pressure gradient reversal mechanism.
【學(xué)位授予單位】：第二軍醫(yī)大學(xué)
【學(xué)位級別】：博士
【學(xué)位授予年份】：2007
【分類號】：R-332;R541.1

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