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  本文選題：Y染色體 + 壯族��； 參考：《廣西醫(yī)科大學(xué)》2006年碩士論文

【摘要】： 壯族是中國最大的少數(shù)民族,與東南亞的泰老族群有著密切的關(guān)系,在東亞人群的遺傳結(jié)構(gòu)研究中地位非常特殊。然而,由于壯民族本身缺乏自己的文字,歷經(jīng)數(shù)千年的發(fā)展,壯民族內(nèi)部人群的遷徙融合及交流狀況很難在現(xiàn)有的文字資料中體現(xiàn)出來,僅從語言上將壯族人群區(qū)分為壯語北部方言組和南部方言組。為了解壯族人群的內(nèi)部遺傳結(jié)構(gòu),我們從父系遺傳Y染色體及母系遺傳mtDNA入手,根據(jù)東亞人群特異的18個Y-染色體雙等位標記,7個Y-STR標記及mtDNA HVSⅠ區(qū)對壯族各個支系共八個人群的DNA樣本進行DNA測序、限制性長度片段多態(tài)酶切、熒光PCR鑒定SNP等實驗技術(shù)分析及主成份分析、聚類分析、分子方差等詳盡的遺傳學(xué)分析技術(shù),調(diào)查了壯族各個支系的DNA多樣性,分別確定其Y-SNP、Y-STR、mtDNA單倍群(單倍型),揭示壯族的內(nèi)部遺傳結(jié)構(gòu)。結(jié)果發(fā)現(xiàn),壯族的主要Y染色體單倍群為O*, O2a, O1。壯族的遺傳結(jié)構(gòu)中有幾個層次,最早的O*、O2a成分普遍出現(xiàn)在各個支系中,第二層是由東部來的百越核心成分O1,第三層是北方來的漢族成分O3,與壯族的歷史事件和其他人類學(xué)研究基本一致;壯族支系遺傳結(jié)構(gòu)體現(xiàn)出以紅水河支系為中心從東往西的梯度變化過程。傳統(tǒng)的對壯族按方言分為南北二組的分類方法在遺傳上并沒有依據(jù)。 壯族mtDNA的數(shù)據(jù)盡管還沒有完成詳細的分析,但是從其mtDNA單倍群的頻率分布來看,壯族也是非常接近百越族群。因此,父系和母系兩方面的遺傳數(shù)據(jù)均顯示,壯族是典型的東亞南方人群。 基本了解壯族人群的遺傳結(jié)構(gòu)以后,壯族人群中一些特殊群體如巴馬壯族長壽老人的遺傳背景即有豐富的對比資料,同時因為這些人群的特殊性也引起了我們的興趣。由于人類長壽顯示明顯的母系遺傳傾向,而線粒
[Abstract]:Zhuang is the largest minority in China and has a close relationship with the Tai-Lao ethnic group in Southeast Asia. It plays a special role in the study of genetic structure of East Asian population. However, due to the lack of their own characters, and after thousands of years of development, the situation of migration, integration and exchange of people within the Zhuang nationality is very difficult to reflect in the existing written materials. The Zhuang nationality is divided into the northern dialect group and the southern dialect group. In order to understand the internal genetic structure of Zhuang people, we start with patrilineal Y chromosome and matrilineal mtDNA. According to 18 Y- chromosome double allelic markers, 7 Y-STR markers and mtDNA HVS I region, DNA samples from 8 individuals of Zhuang nationality were sequenced. The detailed genetic analysis techniques, such as SNP analysis, cluster analysis, molecular variance analysis and so on, were used to investigate the DNA diversity of various branches of Zhuang nationality. The haploidy (haplotype) of Y-SNPGY-STRN mtDNA was determined respectively to reveal the internal genetic structure of Zhuang nationality. The results showed that the main Y chromosome haploidy groups of Zhuang nationality were Oi, O2a, O1. There are several layers in the genetic structure of Zhuang nationality. The second layer is the core component O1 of Baiyue from the east, the third layer is the Han component O3 from the north, which is basically consistent with the historical events of Zhuang nationality and other anthropological studies. The genetic structure of the Zhuang branch reflects the gradient variation process from east to west with the Hongshui River branch as the center. There is no genetic basis for the traditional classification of Zhuang nationality into two groups according to dialects. Although the data of mtDNA of Zhuang nationality has not been analyzed in detail, the frequency distribution of its mtDNA haploidy population shows that Zhuang nationality is also very close to Baiyue ethnic group. Therefore, both paternal and maternal genetic data show that Zhuang is a typical southern East Asian population. After the basic understanding of the genetic structure of Zhuang population, the genetic background of some special groups, such as the Bama Zhuang people, is rich in comparative data, and the particularity of these groups has also aroused our interest. Because the longevity of human beings shows obvious maternal genetic tendency, and the grain of line
【學(xué)位授予單位】：廣西醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2006
【分類號】：R394

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相關(guān)期刊論文 前10條

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2 李輝,潘方芳,張敏華,陳華,張蔚，

本文編號：2105628