本文選題：韁核 + 晝夜節(jié)律　； 參考：《吉林大學(xué)》2006年碩士論文

【摘要】： 韁核是邊緣前腦至中腦的重要樞紐,它與睡眠-覺醒周期相關(guān)的上下位結(jié)構(gòu)均有著密切的神經(jīng)解剖學(xué)聯(lián)系,是參與調(diào)節(jié)晝夜節(jié)律的重要核團(tuán)之一。 褪黑素(MT)由松果腺在光照的導(dǎo)引下和在下丘腦視交叉上核(SCN)的控制下,節(jié)律性地合成和分泌的吲哚胺類激素。白天MT的分泌受到抑制,黑夜MT大量合成和分泌。這種節(jié)律性的分泌方式對(duì)于生物節(jié)律的形成是重要的。 本文采用在急性分離的大乳鼠韁核神經(jīng)元細(xì)胞膜片鉗記錄方法,在晝夜周期的不同時(shí)相(白天的CT10-12;CT12-14;CT14-16和夜晚的CT20-22; CT22-24; CT0-2)記錄韁核延遲整流鉀離子電流,觀察大乳鼠韁核神經(jīng)元延遲整流鉀電流的晝夜節(jié)律性以及褪黑素的作用。 實(shí)驗(yàn)結(jié)果顯示:(1)韁核神經(jīng)元延遲整流鉀電流具有自主的晝夜節(jié)律,電流幅度黑夜高,白天低。(2)無論在白天還是黑夜,褪黑素能明顯增加韁核神經(jīng)元延遲整流鉀電流。(3)褪黑素增加的韁核延遲整流鉀電流的程度在黑夜高,在白天低。這說明韁核神經(jīng)元上的鉀離子通道開放的自主晝夜節(jié)律性可能是韁核神經(jīng)元晝夜節(jié)律性形成的離子基礎(chǔ);褪黑素調(diào)節(jié)韁核的晝夜節(jié)律性可能是通過對(duì)鉀離子電流起作用的,而韁核對(duì)褪黑素的敏感性顯示有晝夜的不同進(jìn)一步提示鉀離子電流在韁核晝夜節(jié)律形成中的作用,其機(jī)制有待更深入的研究。
[Abstract]:Habenular nucleus is an important hub from the marginal forebrain to the midbrain. It has a close neuroanatomical relationship with the upper and lower structures associated with the sleep-wake cycle and is one of the important nuclei involved in the regulation of circadian rhythm. Melatonin (MTT) is rhythmically synthesized and secreted by the pineal gland under the guidance of light and under the control of the supraoptic nucleus of the hypothalamus (SCN). The secretion of MT was inhibited during the day and a large number of MT was synthesized and secreted in the night. This rhythmic way of secretion is important for the formation of biological rhythms. A patch-clamp recording method was used to record delayed rectifier potassium ion currents in habenular nucleus of neonatal rats at different periods of day and night (day CT10-12 CT12-1414 CT14-16 and night CT20-22; CT22-24; CT0-2). To observe the circadian rhythm of delayed rectifier potassium current in habenular nucleus neurons and the effect of melatonin. The results show that the delayed rectifier potassium current of habenula neurons has its own circadian rhythm, the amplitude of current is high in night and night, and the amplitude of current in day is low. Melatonin significantly increased delayed rectifier potassium current in habenular nucleus neurons. This suggests that the spontaneous circadian rhythm of potassium channel opening in habenular nucleus neurons may be the ionic basis of circadian rhythm of habenular nucleus neurons, and melatonin may regulate the circadian rhythm of habenular nucleus by acting on potassium ion currents. The sensitivity of habenular nucleus to melatonin showed diurnal variation further suggesting the role of potassium ion current in the formation of circadian rhythm in habenular nucleus and its mechanism needs further study.
【學(xué)位授予單位】：吉林大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2006
【分類號(hào)】：R33

【參考文獻(xiàn)】

相關(guān)期刊論文 前1條

1 趙華,華樹成,房家智,王紹;韁核神經(jīng)元對(duì)傷害性刺激和壓力感受性刺激的反應(yīng)[J];神經(jīng)解剖學(xué)雜志;1998年02期

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本文編號(hào)：1967037