本文選題：銅綠假單胞菌 + 氨基糖苷類修飾酶��； 參考：《中國(guó)循證醫(yī)學(xué)雜志》2014年07期

【摘要】：目的了解我國(guó)銅綠假單胞菌的氨基糖苷類耐藥基因分布狀況。方法計(jì)算機(jī)檢索CBM、CNKI、VIP和WanFang Data數(shù)據(jù)庫(kù),收集報(bào)道我國(guó)銅綠假單胞菌耐氨基糖苷類基因的研究,檢索時(shí)限均從建庫(kù)至2012年12月。由2位評(píng)價(jià)員按照納入與排除標(biāo)準(zhǔn)篩選文獻(xiàn)、提取資料后,采用SPSS 17.0軟件進(jìn)行統(tǒng)計(jì)分析。結(jié)果共納入10個(gè)省市1 144株耐氨基糖苷類銅綠假單胞菌。氨基糖苷類修飾酶基因aac(3’)-Ⅰ、aac(3’)-Ⅱ、aac(6’)-Ⅰ、aac(6’)-Ⅱ、ant(2’’)-Ⅰ、ant(3’’)-Ⅰ和aph(3’)-Ⅵ在淮河以北地區(qū)的檢出率分別為13.3%、40.1%、21.6%、40.3%、38.1%、23.7%和2.9%,而淮河以南地區(qū)的檢出率分別為3.2%、20.2%、15.9%、37.6%、28.3%、28.5%和9.1%。16S rRNA甲基化酶基因rmtA、rmtB和armA檢出率分別為20.4%、19.4%和0.7%,而其余16S rRNA甲基化酶基因均未檢出。結(jié)論氨基糖苷類修飾酶是我國(guó)銅綠假單胞菌耐氨基糖苷類藥物的主要機(jī)制,而16S rRNA甲基化酶是其次要機(jī)制。
[Abstract]:Objective to investigate the distribution of aminoglycoside resistance genes of Pseudomonas aeruginosa in China. Methods the databases of VIP and WanFang Data were searched by computer, and the studies of aminoglycoside resistance genes of Pseudomonas aeruginosa in China were reported. The searching time was from the establishment of the library to December 2012. The literature was screened by two evaluators according to the inclusion and exclusion criteria, and the data were extracted and analyzed by SPSS 17.0 software. Results A total of 1 144 strains of aminoglycoside resistant Pseudomonas aeruginosa were included in 10 provinces and cities. The detection rates of the aminoglycoside modified enzyme gene aacanine (aacanine)-鈪，

本文編號(hào)：1860599