本文選題：豬 + 急性亞段肺動(dòng)脈栓塞��； 參考：《南京醫(yī)科大學(xué)》2006年碩士論文

【摘要】：目的：1．運(yùn)用介入栓塞技術(shù)建立一種能用于影像學(xué)診斷的豬急性亞段肺動(dòng)脈栓塞模型，并評(píng)價(jià)其技術(shù)上的可行性和準(zhǔn)確性；2．比較多層螺旋CT肺動(dòng)脈造影不同層厚對(duì)亞段肺動(dòng)脈栓塞的顯示能力；3．以肺動(dòng)脈血管鑄型標(biāo)本為金標(biāo)準(zhǔn)，比較多層螺旋CT肺動(dòng)脈造影、數(shù)字減影X線肺動(dòng)脈造影對(duì)亞段肺動(dòng)脈栓塞的顯示能力。 方法：1．5只家豬經(jīng)右側(cè)頸外靜脈注入若干聚氯乙烯(PVC)栓塞劑(直徑2-3mm)，栓塞前后分別做DSPA和CTPA。栓塞成功后24小時(shí)內(nèi)處死動(dòng)物，取出完整豬肺組織。經(jīng)肺動(dòng)脈主干注入適量鑄型劑(32.8％樹(shù)脂溶液)行血管鑄型；2．5只家豬，均用1.0mm準(zhǔn)直掃描進(jìn)行CT肺動(dòng)脈造影，分別用1.0mm／0.5mm(層厚／層間距)(A組)，2.0mm／1.0mm(B組)，，3.0mm／1.5mm(C組)重建，記錄每只家豬3種不同重建層厚顯示亞段肺動(dòng)脈栓塞的敏感性和陽(yáng)性預(yù)測(cè)值；3．5只家豬，分別進(jìn)行數(shù)字減影X線肺動(dòng)脈造影、多層螺旋CT肺動(dòng)脈造影和肺動(dòng)脈血管鑄型，多層螺旋CT肺動(dòng)脈造影圖像分別用1mm、2mm、3mm層厚重建，記錄每只家豬3種不同方法檢測(cè)亞段肺動(dòng)脈栓子的敏感性和陽(yáng)性預(yù)測(cè)值。 結(jié)果：1．5只豬全部成功制作急性亞段肺動(dòng)脈栓塞模型，在DSPA圖像上，亞段肺動(dòng)脈栓塞表現(xiàn)為相應(yīng)區(qū)域的肺動(dòng)脈分支數(shù)減少；在CTPA
[Abstract]:Objective: 1. to establish a model of acute subsegmental pulmonary embolism that can be used for imaging diagnosis by interventional embolization, and to evaluate its technical feasibility and accuracy; 2. compare the ability to display subsegmental pulmonary embolism with different thickness of multi slice spiral CT pulmonary arteriography, and 3. with pulmonary artery vascular cast specimen as gold standard. Comparison of multislice spiral CT pulmonary angiography and digital subtraction pulmonary angiography in demonstrating the ability of subsegmental pulmonary embolism.
Methods: 1.5 domestic pigs were injected with a number of polyvinyl chloride (PVC) embolic agents (diameter 2-3mm) through the right external jugular vein. The animals were killed within 24 hours after embolization with DSPA and CTPA. respectively. The whole lung tissue was taken out. A proper amount of mould agent (32.8% tree fat solution) was injected into the main trunk of the pulmonary artery, and 2.5 domestic pigs were treated with 1.0mm. CT pulmonary angiography was performed by collimated scanning, and the sensitivity and positive predictive value of 3 different reconstructive layer thickness of each pig were recorded with 1.0mm / 0.5mm (layer thickness / interval) (group A), 2.0mm / 1.0mm (group B), 3.0mm / 1.5mm (C group), and 3.5 domestic pigs, respectively, with digital subtraction X-ray pulmonary angiography and multi layer snail, respectively. Spiral CT pulmonary angiography and pulmonary artery cast, multi-slice spiral CT pulmonary angiography images were reconstructed with 1mm, 2mm, 3mm thickness respectively. The sensitivity and positive predictive value of 3 different methods for detecting subsegmental pulmonary emboli were recorded in each pig.
Results: all 1.5 pigs successfully made an acute subsegmental pulmonary embolism model. In the DSPA image, the number of pulmonary artery branches in the corresponding region was reduced by subsegmental pulmonary artery embolization; in CTPA

【學(xué)位授予單位】：南京醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2006
【分類號(hào)】：R-332;R816.4

【參考文獻(xiàn)】

相關(guān)期刊論文 前2條

1 吳春根,周康榮,湯敏,嚴(yán)福華,曾蒙蘇,王佩芬;心電標(biāo)記回顧性肺動(dòng)脈多層螺旋CT血管造影術(shù)(附5例肺動(dòng)脈栓塞)[J];臨床放射學(xué)雜志;2003年04期

2 于麗娟,張雪林,李任飛,劉瑞寶,欒玉,王丹,申寶忠;家兔急性肺栓塞影像模型的制備[J];中國(guó)臨床醫(yī)學(xué)影像雜志;2004年03期

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