本文選題：液態(tài)栓塞材料 + 動脈瘤模型��； 參考：《吉林大學(xué)》2007年碩士論文

【摘要】： 人類顱內(nèi)動脈瘤(Aneurysm,AN)破裂出血常引發(fā)病人出現(xiàn)嚴重的神經(jīng)系統(tǒng)癥狀導(dǎo)致殘廢或死亡,因此常被喻為人腦內(nèi)的“定時炸彈”。其主要治療方法有:外科開顱AN夾閉術(shù)和血管內(nèi)介入栓塞治療。血管內(nèi)介入治療因其無需開刀,創(chuàng)傷小痛苦少,術(shù)后恢復(fù)快日益被腦血管病患者接受,隨著CT血管造影(Computed tomographic angiography,CTA)和磁共振血管造影(Magnetic resonance angiography, MRA)、數(shù)字減影血管造影( Digital subtraction angiography,DSA)等影像學(xué)檢查手段的發(fā)展以及栓塞方法的進步,使得血管內(nèi)介入治療迅速發(fā)展,很多新的栓塞材料不斷出現(xiàn)。成纖維細胞-海藻酸鹽-熱敏脂質(zhì)體是一種新型液態(tài)溫控式、具有生物活性組織修復(fù)功能的栓塞材料,符合栓塞材料未來的發(fā)展方向。但此種栓塞材料的研究目前只進行了體外實驗,臨床實際應(yīng)用的各項指標還需在動物模型上進一步研究,為了給這種栓塞材料的進一步研究提供良好的AN動物模型,本次實驗利用顯微外科靜脈囊移植法制備家豬側(cè)壁型AN模型。通過顯微外科技術(shù)直接將靜脈囊吻合于頸總動脈(Common carotid artery,CCA)側(cè)壁后,于術(shù)后1周行DSA檢查,檢測AN模型的建立是否成功,建立成功率75%;于術(shù)后4周再行DSA檢查,以明確該AN模型的瘤腔內(nèi)附壁血栓形成情況,仍有67%的AN模型保持瘤體、瘤頸結(jié)構(gòu),但均有不同程度附壁血栓形成。通過DSA對AN模型的評估,得出結(jié)論:采用顯微外科手術(shù)靜脈囊移植法技術(shù)建立家豬CCA側(cè)壁型AN模型的方法經(jīng)濟可行;側(cè)壁型AN模型的成功率高、制備操作簡單高效,實驗動物存活率高;便于液態(tài)栓塞材料血管內(nèi)介入栓塞操作及術(shù)后觀察;雖然模型檢測手段各具特點,DSA為最佳評估檢測方法,同時可以為新型液態(tài)栓塞材料實驗進一步研究提供技術(shù)基礎(chǔ);雖然此種側(cè)壁寬頸AN模型自身不適宜血管內(nèi)栓塞的操作,但是我們利用球囊封堵技術(shù)輔助栓塞可以彌補其缺點。
[Abstract]:Rupture and hemorrhage of human intracranial aneurysm Aneurysman often lead to severe neurological symptoms, which lead to disability or death, so it is often referred to as a "time bomb" in human brain. The main treatment methods are: surgical closure of an and endovascular embolization. Intravascular interventional therapy is increasingly accepted by patients with cerebrovascular disease because it does not require surgery and has less pain and pain. With the development of imaging methods such as computed tomographic angiography (CTA), magnetic resonance angiography (MRAA), Digital subtraction angiography (DSAs) and the improvement of embolization methods, endovascular interventional therapy has developed rapidly. Many new embolic materials are emerging. Fibroblast-alginate-thermosensitive liposome is a new type of liquid thermo-controlled embolic material with bioactive tissue repair function, which is in line with the future development of embolic materials. However, the study of this kind of embolization material has only been carried out in vitro, and the indexes of clinical application need to be further studied on animal models. In order to provide a good an animal model for the further study of this kind of embolization material, In this experiment, we used microsurgical venous sac transplantation to prepare an model of swine lateral wall. The venous sac was directly anastomosed to the lateral wall of Common carotid Arteria arteriosus by microsurgical technique. DSA examination was performed at 1 week after operation to detect the success of an model, and the success rate was 75%, and the DSA examination was performed 4 weeks after operation. In order to identify the intraluminal thrombus formation in the an model, 67% of the an models remained the tumor and neck structure, but all had different degree of mural thrombosis. Based on the evaluation of an model by DSA, it is concluded that it is economical and feasible to use microsurgical venous sac transplantation technique to establish CCA side-wall an model in domestic pigs, the success rate of side-wall an model is high, and the preparation of side-wall an model is simple and efficient. The survival rate of experimental animals is high; it is convenient for intravascular embolization of liquid embolization materials and postoperative observation; although model detection methods have their own characteristics, DSA is the best method for evaluation and detection. At the same time, it can provide the technical foundation for the further study of the new liquid embolic material. Although the side-wall wide-neck an model is not suitable for the endovascular embolization, we can make up for its shortcomings by using the balloon occlusion technique to assist the embolization.
【學(xué)位授予單位】：吉林大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2007
【分類號】：R-332

【參考文獻】

相關(guān)期刊論文 前1條

1 李建初,蔡勝,姜玉新,張縉熙;假性動脈瘤的彩色多普勒超聲征象及其臨床意義[J];中華超聲影像學(xué)雜志;2001年08期

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