本文選題：類胰蛋白酶 + 過敏性猝死�。� 參考：《山西醫(yī)科大學》2007年碩士論文

【摘要】： 目的:通過測定免疫正常人群和免疫異常人群血清中類胰蛋白酶的含量,來建立中國免疫正常人群其血清含量的正常值范圍,為過敏性疾病和過敏性猝死提供客觀、準確的依據(jù)。方法:免疫正常人群按年齡分為四組,第一組小于21歲,第二組為21到40歲,第三組41到60歲,第四組大于60歲。免疫異常人群按疾病分為五組,分別為哮喘組、濕疹組、腎炎組、類風濕關節(jié)炎組、肝硬化組。收集不同死因的尸體心血4例。使用UniCAP 100過敏原自動檢測儀,利用熒光免疫酶技術(FEIA)測定其血清中類胰蛋白酶的含量。結(jié)果:(1)正常人血清中tryptase含量的幾何均數(shù)為2.69μg/L,95%分位數(shù)為6.00μg/L。正常人血清中tryptase的含量,男性均值為3.33±1.63μg/L,女性均值為2.80±1.40μg/L,男女之間的差別無統(tǒng)計學意義;四個年齡組組間比較:第1、2、3組均值分別為2.56±1.44μg/L、2.90±1.32μg/L、2.92±1.17μg/L,第4組均值為3.87±2.04μg/L,和1、2、3組相比均有明顯差異,比前三個組的均值高。(2)哮喘組均值為6.14±0.35μg/L,濕疹組均值為2.22±1.73μg/L,腎炎組均值為0.80±0.21μg/L,類風濕關節(jié)炎組均值為10.42±12.52μg/L,肝硬化組均值為3.13±1.73g/L,正常人組均值為3.06±1.53μg/L。哮喘和類風濕關節(jié)炎病人的均值比正常人的均值高;濕疹、腎炎和肝硬化病人的均值與正常人相比,無明顯差異。(3)4例尸體心血中類胰蛋白酶的含量分別為24.00μg/L、6.71μg/L、4.83μg/L、19.7μg/L。 結(jié)論:(1)中國免疫正常人群血清中類胰蛋白酶的含量,幾何均數(shù)為2.69μg/L,正常范圍為[0,6.00]μg/L。其含量無性別差異,但年齡因素對其有一定影響。(2)哮喘和類風濕關節(jié)炎病人血清中類胰蛋白酶的含量要高于正常人,濕疹、腎炎和肝硬化病人血清中類胰蛋白酶的含量與正常人相比無明顯差異。(3)吸毒和外傷致死的尸體血清中類胰蛋白酶的含量要遠遠高于正常人,而動脈粥樣硬化致死的尸體其含量則無明顯變化。
[Abstract]:Objective: to establish the normal range of serum content of Chinese immune normal population by measuring the content of trypsin like trypsin in serum of normal immune people and immune abnormal crowd, to provide objective and accurate basis for allergic diseases and sudden sudden death. Methods: the normal immune population was divided into four groups according to age, the first group was less than 21 years old and second. The group was 21 to 40 years old, third groups 41 to 60 years old and fourth groups more than 60 years old. The immune abnormal people were divided into five groups according to the disease. They were asthma group, eczema group, nephritis group, rheumatoid arthritis group, liver cirrhosis group. The body blood of different causes of death was collected in 4 cases. The UniCAP 100 allergen automatic test instrument was used and the serum FEIA was used to determine its serum. Results: (1) the geometric mean of tryptase content in normal human serum was 2.69 mu g/L, and the number of 95% quantiles was 6 mu g/L. in normal human serum, the mean value of male was 3.33 + 1.63 g/L, the mean value of women was 2.80 + 1.40 u g/L, and there was no statistical difference between men and women; four age groups were compared: 1,2,3 The mean value of the group was 2.56 + 1.44 g/L, 2.90 + 1.32 mu g/L and 2.92 + 1.17 u g/L, and the mean value of the fourth group was 3.87 + 2.04 mu g/L. Compared with the 1,2,3 group, the mean value was higher than the average of the previous three groups. (2) the mean of the asthma group was 6.14 + 0.35 mu g/L, the mean of the eczema group was 2.92 + 1.17 g/L, and the mean of the nephritis group was + + g/L, and the average of the rheumatoid arthritis group was The mean value of.42 + 12.52 mu g/L, the mean of liver cirrhosis was 3.13 + 1.73g/L, the mean value of the normal people was 3.06 + 1.53 mu g/L. asthma and rheumatoid arthritis, the mean value was higher than that of the normal people. The mean value of the patients with eczema, nephritis and liver cirrhosis was not significantly different from those of the normal people. (3) the content of trypsin like trypsin in the heart and blood of 4 cadavers was 24 g/L, 6.7 respectively. 1 mu g/L, 4.83 mu g/L, 19.7 mu g/L.
Conclusions: (1) the content of trypsin like tryptase in the serum of Chinese immune normal population is 2.69 g/L, and the normal range is [0,6.00] g/L. without sex difference, but the age factors have some influence on it. (2) the serum level of leuzase in serum of patients with asthma and rheumatoid arthritis is higher than that of normal people, eczema, nephritis and cirrhosis of the liver. There was no significant difference in the content of tryptase in the serum of the patients. (3) the content of trypsin like tryptase in the corpse of the dead body of drug and trauma was much higher than that of the normal person, while the content of the corpse died of atherosclerosis had no significant change.

【學位授予單位】：山西醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2007
【分類號】：R363

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