本文選題：吞噬細胞　切入點：凋亡細胞　出處：《細胞與分子免疫學雜志》2014年02期

【摘要】：正常組織新陳代謝中會產生大量的凋亡細胞,它們作為機體自身抗原的主要來源在誘導免疫耐受中發(fā)揮重要的作用。脾臟邊緣區(qū)的巨噬細胞(如邊緣區(qū)巨噬細胞和邊緣區(qū)嗜金屬巨噬細胞等)和脾臟中的樹突狀細胞通過"find-me"信號"eatme"信號快速識別并清除體內不斷產生的凋亡細胞,以致于在體內很難檢測到凋亡細胞。同時,凋亡細胞的清除可誘導機體對自身抗原的免疫耐受。并且已有研究指出,清除凋亡細胞誘導免疫耐受這一理論已被用于預防自身免疫病和誘導腫瘤免疫。本文主要綜述了機體清除凋亡細胞的分子機制及臨床意義。
[Abstract]:In normal tissue metabolism, a large number of apoptotic cells are produced. They play an important role in inducing immune tolerance as the main source of body autoantigen. Macrophages in the marginal region of the spleen (such as macrophages in the marginal region and metal macrophages in the marginal region) and dendrites in the spleen. The "find-me" signal, "eatme" signal, is used by the cells to quickly recognize and clear the cells that are constantly producing apoptosis in the body. That makes it difficult to detect apoptotic cells in vivo. At the same time, the removal of apoptotic cells can induce the body's immune tolerance to its own antigens. The theory of immune tolerance induced by scavenging apoptotic cells has been used to prevent autoimmune diseases and induce tumor immunity. The molecular mechanism and clinical significance of scavenging apoptotic cells were reviewed in this paper.
【作者單位】： 山東大學醫(yī)學院;山東大學細胞生物學研究所;
【基金】：國家自然科學基金(81202306) 山東大學自主創(chuàng)新基金(2011TB013)
【分類號】：R392

【相似文獻】

相關期刊論文 前10條

1 陳瑞新,許善錦,王夔,趙，

本文編號：1693106