本文選題：大林姬鼠　切入點(diǎn)：褐家鼠　出處：《四川大學(xué)》2005年碩士論文

【摘要】：漢坦病毒(Hantavirus,HV)屬于布尼亞病毒科(Bunyyaviridae)漢坦病毒屬(Hantavirus),是一有包膜的分節(jié)段的負(fù)鏈RNA病毒。HV基因組由大(Large,L)、中(Medium,M)、小(Small,S)三個(gè)片段組成。L片斷長(zhǎng)6530-6550bp,編碼病毒特異的依賴RNA的RNA聚合酶;M片斷大小3613-3707bp,編碼G蛋白前體(GPC);S片斷由1696-2083bp組成,編碼病毒的核衣殼蛋白(NP)。 漢坦病毒一個(gè)主要特征是每一型的HV都有一個(gè)獨(dú)特的嚙齒動(dòng)物宿主(除TPM株以外)。漢坦病毒可在其宿主中長(zhǎng)期存在而不表現(xiàn)癥狀,并與宿主共進(jìn)化。人主要通過(guò)接觸帶毒宿主動(dòng)物及其分泌物和排泄物所形成的氣溶膠而感染。人感染HV后可引起兩種死亡率很高的疾病:腎綜合征出血熱(Hemorrhagic Fever with Renal Syndrome,HFRS)和漢坦病毒肺綜合征(Hantavirus Pulmony Syndrome,HPS)。 目前,已有23種漢坦病毒的血清型/基因型被確定。我國(guó)流行的主要是Ⅰ(HTN)型和Ⅱ(SEO)型漢坦病毒。最近有報(bào)導(dǎo)在我國(guó)發(fā)現(xiàn)普馬拉(PW)型漢坦病毒。 本研究共分為兩個(gè)部分: 1、用直接免疫熒光法檢測(cè)從吉林省不同疫區(qū)采集的褐家鼠鼠肺標(biāo)本,共得到55份陽(yáng)性標(biāo)本,陽(yáng)性率為9.35%;將其中4個(gè)陽(yáng)性標(biāo)本(Jilin1050、Jilin1055、Jilin1056和Jilin1060)作RT-PCR檢測(cè),結(jié)果為SEO(Ⅱ)型病
[Abstract]:Hantavirus HV) belongs to Bunyaviridae.Hantavirus.Hantavirus.HV is a coated, segmented, negative stranded RNA virus .HV genome is composed of three fragments of large large LU, Mediumanus Mimanus, SmallS3 (6530-6550bplong, encoding the virus-specific RNA dependent RNA Polymer). The M fragment of synthase was 3613-3707bp.The fragment encoding G-protein precursor was composed of 1696-2083bp. Nucleocapsid protein (NPN) encoding the virus. A major feature of Hantavirus is that each type of HV has a unique rodent host (other than the TPM strain). And coevolution with the host. Human infection is mainly through contact with aerosol from the host animal with virus and its secretions and excreta. Human infection with HV can cause two diseases with high mortality: hemorrhagic fever with renal syndrome, hemorrhagic fever with renal syndrome, Fever with. Renal and Hantavirus Pulmony. At present, 23 Hantavirus serotypes / genotypes have been identified. The main prevalent Hantaviruses in China are type 鈪，

本文編號(hào)：1683659