本文選題：邊緣區(qū)　切入點(diǎn)：紋狀體　出處：《第一軍醫(yī)大學(xué)》2005年博士論文

【摘要】：腦紋狀體邊緣區(qū)(marginal division,MrD)是舒斯云等1987年在研究大鼠腦紋狀體時發(fā)現(xiàn)的位于新紋狀體尾內(nèi)側(cè)、環(huán)繞蒼白球頭外側(cè)的一個由梭形細(xì)胞構(gòu)成的新亞區(qū),隨后在貓、猴和人腦內(nèi)也發(fā)現(xiàn)存在類似的結(jié)構(gòu),其富含多種神經(jīng)肽類陽性纖維、終末和胞體,與腦內(nèi)包括海馬、杏仁核、Meynert氏基核和前額葉皮質(zhì)等多個學(xué)習(xí)記憶相關(guān)腦區(qū)存在著結(jié)構(gòu)和/或功能上的聯(lián)系,是一個在細(xì)胞形態(tài)、神經(jīng)遞質(zhì)和受體等生物大分子的分布,以及纖維聯(lián)系方面均有別于紋狀體其他部位的獨(dú)特的亞區(qū)。該區(qū)富含SP、5-HT、DA、L-ENK、NT、SOM和TH等多種神經(jīng)肽陽性纖維和胞體。該區(qū)和Meynert基底核及黑質(zhì)等部位均有纖維聯(lián)系。而且,己證實(shí)大鼠的MrD參與了電Y迷宮厭暗逃避條件反射聯(lián)合型學(xué)習(xí),在相同的行為模式訓(xùn)練后可觀察到大鼠MrD細(xì)胞有c-fos、c-jun即早基因和與長期記憶形成密切相關(guān)的細(xì)胞核轉(zhuǎn)錄調(diào)節(jié)因子pCREB表達(dá)。最近,又進(jìn)一步發(fā)現(xiàn)MrD涉及人的聽覺數(shù)字工作記憶,臨床上也觀察到因MrD受損而出現(xiàn)認(rèn)知功能障礙的患者。 多巴胺(DA)是腦中豐富的兒茶酚胺類神經(jīng)遞質(zhì),廣泛參與運(yùn)動、認(rèn)知、學(xué)習(xí)與記憶、情感、內(nèi)分泌、正性強(qiáng)化等多種生理功能的調(diào)節(jié)。帕金森氏病、精神分裂癥、抽動穢語綜合征(Tourette's syndrome)、藥物成癮、高泌乳素血癥等疾病都與多巴胺遞質(zhì)傳遞障礙有關(guān)。多巴胺發(fā)揮生理、病理等方面的作用是
[Abstract]:The marginal division of the striatum (Mr D) is a new subregion of fusiform cells found in the caudal part of the neo striatum, surrounding the lateral part of the globus pallidus, and then in cats, by Schusyun et al., in 1987, when he studied the striatum in rats. Similar structures have been found in monkeys and human brains, rich in a variety of neuropeptide positive fibers, terminals and cell bodies, and the brain, including the hippocampus, There are structural and / or functional connections in several learning and memory related brain areas, such as the Meynert's basal nucleus and the prefrontal cortex of the amygdala, which is a distribution of biological macromolecules such as cell morphology, neurotransmitters and receptors. This region is rich in many kinds of neuropeptide positive fibers and cell bodies, such as SPN5-HTTDAL-ENKSM-SOM and th. There are fiber connections between the region and the basal nucleus and substantia nigra of Meynert, and the relationship between the region and the basal nucleus of Meynert and substantia nigra is also found in this region, which is different from that in other parts of the striatum. It has been proved that the MrD of rats is involved in the combined learning of electrical Y maze, anaerobic and dark escape conditioned reflex. The expression of c-fos-c-jun, an early gene and nuclear transcription regulator pCREB, which is closely related to long-term memory formation, was observed in rat MrD cells after training in the same behavior pattern. Recently, it was further found that MrD is involved in human auditory digital working memory. Patients with cognitive impairment due to MrD impairment were also observed clinically. Dopamine (DA) is a rich catecholamine-like neurotransmitter in the brain, which is widely involved in the regulation of many physiological functions, such as motor, cognition, learning and memory, emotion, endocrine, positive reinforcement, etc. Tourette syndrome, drug addiction, hyperprolactinemia and other diseases are all related to dopamine transmitter transmission disorders. Dopamine plays a physiological and pathological role
【學(xué)位授予單位】：第一軍醫(yī)大學(xué)
【學(xué)位級別】：博士
【學(xué)位授予年份】：2005
【分類號】：R338

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