本文選題：慢性嗎啡處理　切入點：恐懼消退　出處：《南華大學》2007年碩士論文　論文類型：學位論文

【摘要】： 目的:恐懼消退異�；蛉毕莩е陆箲]障礙等疾病發(fā)生;另一方面,流行病學調查表明阿片濫用人群焦慮障礙等情感性疾病的發(fā)生率明顯高于正常人群,其機制仍不清楚。本研究擬檢測慢性嗎啡處理是否損傷大鼠條件化恐懼消退過程,以期探討阿片濫用伴焦慮障礙的可能神經機制。 方法:連續(xù)10天嗎啡處理(sc,遞增劑量模式,每天2次),建立阿片依賴動物模型。戒斷后28小時與第7天,行自發(fā)戒斷癥狀檢測。戒斷后第7天,行線索性(聲刺激與足底電擊配對)或場景性(特定場景與足底電擊配對)恐懼條件化訓練;第8天至第11天,行線索性(聲刺激單獨呈現)或場景性(場景單獨呈現)恐懼消退訓練(每天1次);行為檢測指標為聲刺激或場景誘發(fā)的僵直時間。非特異性反應的檢測包括:痛域(熱水浴甩尾法、活動度)、聲刺激非特異性僵直與場景非特異性僵直。 結果:1、戒斷后28小時,嗎啡組大鼠與生理鹽水組大鼠相比表現出明顯的戒斷癥狀;戒斷后第7天,戒斷癥狀不明顯。2、在線索性恐懼條件化階段,嗎啡組僵直時間與生理鹽水組相比無顯著性差異;在線索性恐懼消退階段,嗎啡組僵直時間顯著性高于生理鹽水組,但每次消退訓練期間的消退比率無顯著性組間差異。3、在場景性恐懼條件化與恐懼消退階段,嗎啡組僵直時間與生理鹽水組相比均無顯著性差。4、非特異性反應檢測均無顯著性組間差異。 結論:1、本實驗嗎啡處理程序能可靠地誘導大鼠對嗎啡的依賴。2、慢性嗎啡處理損傷長時程線索性恐懼消退記憶,而對短時程線索性恐懼消退記憶無影響,該損傷效應并非慢性嗎啡處理導致非特異性反應改變而引起。3、慢性嗎啡處理對場景性恐懼條件化與恐懼消退無影響。4、慢性嗎啡處理所致恐懼消退缺陷可能介導了阿片濫用伴焦慮障礙等情感性疾病發(fā)生。
[Abstract]:Objective: abnormal or defective fear regression often leads to the occurrence of anxiety disorder. On the other hand, epidemiological investigation shows that the incidence of affective diseases such as anxiety disorder in opioid abusing population is significantly higher than that in normal population. In order to explore the possible neural mechanism of opioid abuse with anxiety disorder, the present study is to examine whether chronic morphine treatment can damage the process of conditioned fear regression in rats. Methods: the animal model of opioid dependence was established by morphine treatment for 10 consecutive days, with an increasing dose pattern, twice a day. The symptoms of spontaneous withdrawal were detected at 28 hours and 7 days after withdrawal, and 7 days after withdrawal. Fear conditioning training (acoustic stimulation and plantar shock pairing) or scene (specific scenario and plantar shock pairing); from day 8 to day 11, Fear retreat training was performed for cues (acoustic stimuli alone) or scene (scene alone) (1 time per day); behavior testing was measured by the time of stiffness induced by acoustic stimulation or scene. Detection of nonspecific responses included:. Pain area (hot water bath tail flick method, Range of activity, acoustic stimulation of non-specific stiffness and scene non-specific stiffness. Results at 28 hours after withdrawal, the morphine group showed obvious withdrawal symptoms compared with the normal saline group, and on the 7th day after withdrawal, the withdrawal symptoms were not obvious. The stiffness time of morphine group was significantly higher than that of saline group, while that of morphine group was significantly higher than that of saline group. However, there was no significant difference in the regression ratio between groups during each receding training period, but in the phase of scene fear conditioning and fear regression, there was no significant difference between the two groups. There was no significant difference in stiffness time between morphine group and saline group, and there was no significant difference in nonspecific reaction between groups. ConclusionThe morphine treatment program can reliably induce morphine dependence in rats, chronic morphine treatment can induce long-term clue fear fading memory, but it has no effect on short-term clue fear regression memory. The damage effect was not caused by the non-specific response change induced by chronic morphine treatment. Chronic morphine treatment had no effect on situational fear conditionality and fear regression. The defect of fear regression induced by chronic morphine treatment may mediate. Opioid abuse with anxiety disorders and other affective disorders occur.
【學位授予單位】：南華大學
【學位級別】：碩士
【學位授予年份】：2007
【分類號】：R363

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本文編號：1652278