本文選題：骨髓　切入點：間充質(zhì)干細胞　出處：《鄭州大學》2005年碩士論文　論文類型：學位論文

【摘要】：近年來,急、慢性缺血性心臟病(ischemic heart disease,IHD)的基礎(chǔ)研究和臨床治療均有較大的進展,尤其是心血管藥物治療學和心臟介入技術(shù)水平不斷提高,急性心肌梗死(acute myocardial infarction,AMI)的死亡率明顯下降,但心肌梗死后心功能衰竭的發(fā)病率和致殘率仍居高不下,已成為危害人類健康的主要疾患之一。目前臨床治療缺血性心臟病的常用治療手段主要包括藥物治療、內(nèi)科介入治療、外科手術(shù)治療等。這些治療方法的主要作用是改善局部血運,挽救瀕死心肌,增加存活心肌功能,而非針對病變冠狀動脈的再造和梗死心肌再生、重建的根本性治療方法。干細胞的研究和應(yīng)用為心肌壞死性疾病提供了新的治療方法。 細胞治療(cellular therapy)通過移植功能細胞,替代、修復(fù)或加強受損的組織或器官的生物學功能,已成為治療多種組織壞死性疾病的新策略。細胞移植(cellular transplantation)、心肌再生(myocardial regeneration),可以增加梗死區(qū)功能心肌細胞數(shù)量,改善心肌功能,逆轉(zhuǎn)心室重塑,是目前研究的熱點。骨髓間充質(zhì)干細胞(mesenchymal stem cell,MSCs)因其獨特的生物學特性在干細胞研究領(lǐng)域倍受重視。骨髓中有兩種類型干細胞,造血干細胞(hematopoietic stem cell,HSC)和間充質(zhì)干細胞。骨髓MSCs是存在于骨髓基質(zhì)內(nèi)的非造血細胞來源的細胞亞群,是中胚層發(fā)育的早期細胞,不僅可以分化為造血實質(zhì)和造血基質(zhì)細胞,還可以分化為許多造血以外的組織,特別是中胚層和神經(jīng)外胚層來源組織的細胞。研究發(fā)現(xiàn)MSCs在體內(nèi)或體外誘導(dǎo)條件下可以分化為心肌樣
[Abstract]:In recent years, the basic research and clinical treatment of ischemic heart disease (IHD) in patients with acute and chronic ischemic heart disease have made great progress, especially the level of cardiovascular drug therapy and cardiac interventional techniques. The mortality rate of acute myocardial myocardial infarction (AMI) decreased significantly, but the incidence and disability rate of heart failure remained high after myocardial infarction. It has become one of the major diseases endangering human health. At present, the commonly used methods of clinical treatment for ischemic heart disease include drug therapy, interventional therapy of internal medicine, The main effects of these treatments are to improve local blood flow, save the dying myocardium, and increase the function of the viable myocardium, rather than for the reconstruction of the diseased coronary artery and the regeneration of the infarcted myocardium. The research and application of stem cells provide a new treatment for myocardial necrosis disease. To replace, repair, or strengthen the biological function of a damaged tissue or organ by transplanting functional cells. Cell transplantation and myocardial regeneration can increase the number of myocardial cells in infarcted area, improve myocardial function and reverse ventricular remodeling. Bone marrow mesenchymal stem cells have attracted much attention in the field of stem cell research because of their unique biological characteristics. There are two types of stem cells in bone marrow. Hematopoietic stem cells and mesenchymal stem cells. Bone marrow MSCs is a subgroup of non-hematopoietic cells that exist in bone marrow stroma and is an early stage of mesoderm development. It can not only differentiate into hematopoietic parenchyma and hematopoietic stromal cells, but also differentiate into hematopoietic parenchyma and hematopoietic stromal cells. It can also differentiate into cells from many tissues other than hematopoiesis, especially mesoderm and neuroectoderm. It has been found that MSCs can differentiate into cardiomyocytes in vivo or in vitro.
【學位授予單位】：鄭州大學
【學位級別】：碩士
【學位授予年份】：2005
【分類號】：R329.2

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