本文關(guān)鍵詞： 腎陽虛證 急性心肌梗死 血液流變學(xué) 血流動(dòng)力學(xué)　出處：《吉林大學(xué)》2007年碩士論文　論文類型：學(xué)位論文

【摘要】： 在目前的中藥藥理研究中,絕大多數(shù)動(dòng)物實(shí)驗(yàn)還是采用西醫(yī)病因病理復(fù)制動(dòng)物模型,只強(qiáng)調(diào)“病”,而忽略了“證”,很難通過動(dòng)物模型反映中醫(yī)“辨證施治”的治療原則。例如當(dāng)前在研究治療胸痹心痛的中藥時(shí),通常選用大鼠急性心肌梗死病理模型進(jìn)行評(píng)價(jià),忽視了中醫(yī)的征候。而臨床上的胸痹心痛可見多種中醫(yī)的“證”,如“腎陽虛證”。但單純西醫(yī)的病理模型是否可以代替中醫(yī)的“證”與“病”并存的征候模型,尚無前人報(bào)道。 為確證“病”和“證”相統(tǒng)一的實(shí)驗(yàn)動(dòng)物模型是否能科學(xué)的評(píng)價(jià)中藥的藥效特點(diǎn),以便更好地指導(dǎo)中藥的新藥開發(fā)和研究,我們在大鼠皮下注射醋酸氫化可的松建立腎陽虛模型的基礎(chǔ)上,結(jié)扎冠狀動(dòng)脈前降支24h建立了“腎陽虛證”下急性心肌梗死模型,觀測形態(tài)學(xué)、血液流變學(xué)、血流動(dòng)力學(xué)、心血管系統(tǒng)相關(guān)因子等指標(biāo),同時(shí)采用西藥(硝酸甘油注射液)和中藥(苦碟子注射液)進(jìn)行藥物干預(yù),探討單純急性心肌梗死與“腎陽虛證”下急性心肌梗死的相關(guān)性。 結(jié)果表明,心肌形態(tài)學(xué)、血液流變學(xué)、血流動(dòng)力學(xué)、心血管系統(tǒng)相關(guān)因子等指標(biāo)變化程度在“單純”急性心肌梗死模型與“腎陽虛證”下急性心肌梗死模型之間沒有明顯差異,而且與西藥和中藥的干預(yù)作用結(jié)果亦相一致。提示在研究治療胸痹心痛中藥時(shí),大鼠“單純”急性心肌梗死可直接作為評(píng)價(jià)藥效的模型,無須建立“腎陽虛證”與“急性心肌梗死”并存的實(shí)驗(yàn)動(dòng)物模型。
[Abstract]:In the current pharmacological study of traditional Chinese medicine, the majority of animal experiments are still using Western medicine etiology and pathology to make animal models. It is difficult to reflect the treatment principle of TCM "differentiation and treatment" through animal models. For example, in the current research on traditional Chinese medicine for treating chest arthralgia and heart-ache, the pathological model of acute myocardial infarction in rats is usually selected for evaluation. The clinical symptoms of TCM were ignored, and many kinds of TCM "syndromes" could be seen in clinical chest arthralgia and heartache pain, such as "Kidney-Yang deficiency Syndrome". However, whether the pathological model of pure western medicine can replace the symptom model of TCM "syndrome" and "disease" has not been reported before. In order to confirm whether the unified animal model of "disease" and "syndrome" can scientifically evaluate the pharmacodynamic characteristics of traditional Chinese medicine, in order to better guide the development and research of new drugs of traditional Chinese medicine, On the basis of hypodermic injection of hydrocortisone acetate to establish the model of kidney yang deficiency, we established the acute myocardial infarction model under "kidney yang deficiency syndrome" after 24 h ligation of anterior descending branch of coronary artery, and observed morphology, hemorheology and hemodynamics. Cardiovascular system related factors and western medicine (nitroglycerin injection) and Chinese medicine (Kudiezi injection) were used to study the correlation between pure acute myocardial infarction and acute myocardial infarction under "deficiency of kidney-yang syndrome". The results showed that myocardial morphology, hemorheology, hemodynamics, There was no significant difference in the changes of cardiovascular system related factors between the "pure" acute myocardial infarction model and the "kidney-yang deficiency" acute myocardial infarction model. The results are consistent with those of western medicine and traditional Chinese medicine. It is suggested that "simple" acute myocardial infarction can be used as a model for evaluating drug efficacy in the study of traditional Chinese medicine for the treatment of chest arthralgia and heart-ache. There is no need to establish the experimental animal model of "Kidney Yang deficiency Syndrome" and "Acute Myocardial Infarction".
【學(xué)位授予單位】：吉林大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2007
【分類號(hào)】：R-332

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