本文關(guān)鍵詞：乳酸桿菌膜表達(dá)幽門螺桿菌黏附素HpaA的活菌載體疫苗株的構(gòu)建及保護(hù)效果研究　出處：《四川大學(xué)》2006年博士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 幽門螺桿菌 乳酸桿菌 活菌疫苗 黏附素A 膜表達(dá)

【摘要】：背景及目的：幽門螺桿菌(Helicobacter pylori，Hp)是慢性胃炎、消化性潰瘍的主要致病因素，也是胃癌和胃黏膜相關(guān)淋巴組織淋巴瘤的主要誘發(fā)因子，世界衛(wèi)生組織已將其列為Ⅰ類致癌物質(zhì)。據(jù)調(diào)查，全球約有一半人存在著Hp感染，是迄今所知人類感染率最高的慢性感染性細(xì)菌。以抗生素為主的三聯(lián)療法具有費(fèi)用高、患者依從性差、耐藥菌增加及腸道菌群失調(diào)等缺點(diǎn)，難以應(yīng)用于全球范圍內(nèi)的Hp控制。特別是對(duì)于占絕大多數(shù)的無癥狀感染者和兒童感染者是否需要應(yīng)用抗生素治療仍存在很大爭(zhēng)議。疫苗將成為控制Hp感染最經(jīng)濟(jì)有效的手段。迄今為止，，包括超聲粉碎菌體及重組亞單位蛋白等多種Hp抗原已經(jīng)有了廣泛研究甚至進(jìn)入臨床試驗(yàn)，并已采取了多種免疫方案。結(jié)果表明，絕大多數(shù)疫苗由于免疫原性有限，需要同時(shí)應(yīng)用CT和LT之類的強(qiáng)效佐劑方能引起有效的保護(hù)性免疫，而這些佐劑具有一定的毒性限制了其人體應(yīng)用。以減毒沙門菌作為載體所構(gòu)建的活菌疫苗能夠部分保護(hù)機(jī)體抵抗Hp感染，但同樣具有潛在毒性難以在人群中廣泛應(yīng)用，特別是對(duì)嬰兒和老人等免疫力較低的人群。 乳酸桿菌是人體正常菌群，以其作為疫苗傳遞載體具有很多優(yōu)點(diǎn)。作為食品生產(chǎn)和保存添加劑，乳酸桿菌在世界范圍內(nèi)已經(jīng)有幾百年的應(yīng)用歷史，具有公認(rèn)的安全性。
[Abstract]:Background and objective: Helicobacter pylori (Helicobacter pylori Hp) is a chronic gastritis, the main pathogenic factor for peptic ulcer, and gastric cancer and gastric mucosa associated lymphoid tissue lymphoma of the main inducing factor, the WHO has been classified as a class I carcinogen. According to the survey, about half of the world the existence of Hp infection. Is known to the human infection rate of chronic bacterial infection. The highest triple therapy by antibiotics with high cost, poor patient compliance, drug resistant strains and disorder of intestinal flora and other shortcomings, Hp control is difficult to be applied in the global scope. Especially the need for antibiotic treatment for asymptomatic infection and children the majority of infected persons still controversial. Vaccine control Hp infection will become the most economical and effective means. So far, including a variety of ultrasonic crushing bacteria and the recombinant subunit protein. Hp antigen has been widely research even in clinical trials, and has taken a variety of immune scheme. The results show that the vast majority of vaccines due to limited immunogenicity, requires intensive adjuvant application of CT and LT at the same time, can induce protective immune adjuvant, which has certain toxicity limits its application in human body. Attenuated Salmonella as live vaccine vector constructed to protect against Hp infection, but also has potential toxicity can not be widely used in the crowd, especially for infants and the elderly people with low immunity.
Lactobacillus is a normal human flora. As a vaccine delivery carrier, lactobacilli has many advantages. As a food production and storage additive, lactobacillus has been applied in the world for hundreds of years, and it has generally recognized safety.

【學(xué)位授予單位】：四川大學(xué)
【學(xué)位級(jí)別】：博士
【學(xué)位授予年份】：2006
【分類號(hào)】：R392.1

【引證文獻(xiàn)】

相關(guān)碩士學(xué)位論文 前1條

1 付強(qiáng);云南撒尼乳餅中乳酸菌的功能特性研究[D];昆明醫(yī)學(xué)院;2011年

本文編號(hào)：1398672