本文關(guān)鍵詞：花生四烯酸敏感和機(jī)械牽張門(mén)控的雙孔鉀離子通道TREK-1、TREK-2和TRAAK的生理和病理功能研究　出處：《中國(guó)協(xié)和醫(yī)科大學(xué)》2005年博士論文　論文類(lèi)型：學(xué)位論文

  更多相關(guān)文章： 鉀離子通道 雙孔鉀離子通道 TREK-1 TREK-2 TRAAK 中樞體溫感受器 急性腦缺血 腦保護(hù)

【摘要】：雙孔鉀離子通道(tandem-pore-domain potassium channels，K_(2P))是近年來(lái)新發(fā)現(xiàn)的一大類(lèi)鉀離子通道，它們?cè)诮Y(jié)構(gòu)上與傳統(tǒng)的鉀離子通道差異很大，具有獨(dú)特的4次跨膜片段(M1～M4)和兩個(gè)孔道結(jié)構(gòu)域(P1和P2)，即4TMS／2P結(jié)構(gòu)。其中TREK-1、TREK-2和TRAAK由于序列結(jié)構(gòu)和調(diào)控機(jī)制的相似性成為一類(lèi)(TREK)。研究發(fā)現(xiàn)，它們?cè)谥袠猩窠?jīng)系統(tǒng)的神經(jīng)元上有特異性的分布。此外，研究表明，除了在人類(lèi)有表達(dá)外，它們?cè)诖笮∈笾幸灿斜磉_(dá)。 TREK鉀離子通道電流具有自發(fā)性、電壓和時(shí)間依賴(lài)性、無(wú)失活等特性。TREK鉀離子通道最顯著的特征在于可以被花生四烯酸等多不飽和脂肪酸和機(jī)械牽張強(qiáng)烈激活，而飽和脂肪酸則沒(méi)有該作用。TREK類(lèi)雙孔鉀離子通道的另外一個(gè)電生理特性在于，，它們對(duì)于經(jīng)典的鉀通道阻斷劑如4-AP、TEA、Cs~+等不敏感。在生理情況下，TREK可以和其它的雙孔鉀離子通道一起產(chǎn)生可興奮細(xì)胞的漏電流，影響細(xì)胞的興奮性。 TREK鉀離子通道的獨(dú)特的結(jié)構(gòu)特征、特異性分布及調(diào)節(jié)方式提示，它們?cè)谥袠猩窠?jīng)系統(tǒng)中可能有獨(dú)特的重要作用。我們的研究致力于揭示該類(lèi)鉀離子通道在中樞神經(jīng)系統(tǒng)的體溫調(diào)節(jié)中樞的體溫調(diào)節(jié)和急性腦缺血中的作用，深入闡明它們的生理和病理作用。 第一部分 花生四烯酸敏感和機(jī)械牽張門(mén)控的雙孔鉀離子通道TREK-1在大鼠中樞體溫調(diào)節(jié)中的作用
[Abstract]:Tandem-pore-domain potassium channels are a new class of potassium channels discovered in recent years. Their structures are very different from the traditional potassium channels, and they have four unique transmembrane fragments (M1M4) and two pore domains (P1 and P22). TREK-1TREK-2 and TRAAK are a kind of TREK-2 because of the similarity of sequence structure and regulatory mechanism. In addition, studies have shown that they are expressed not only in humans, but also in mice and mice. The current of TREK potassium channel is spontaneous, voltage and time dependent. The most significant feature of the Trk potassium channel is that it can be strongly activated by polyunsaturated fatty acids such as arachidonic acid and mechanical distraction. But saturated fatty acids do not have this effect. Another electrophysiological characteristic of TREK bimodal potassium channels is that they are effective against classical potassium channel blockers such as 4-APTEA. Under physiological conditions TREK can produce the leakage current of excitable cells together with other two-pore potassium channels and affect the excitability of cells. The unique structural characteristics, specific distribution and regulation mode of TREK potassium ion channels are suggested. They may play a unique role in the central nervous system. Our research has focused on revealing the role of these potassium channels in central nervous system thermoregulation and acute cerebral ischemia. Their physiological and pathological functions are elucidated in depth. The role of arachidonic acid sensitive and mechanically tension-gated two-pore potassium channel TREK-1 in central thermoregulation in rats
【學(xué)位授予單位】：中國(guó)協(xié)和醫(yī)科大學(xué)
【學(xué)位級(jí)別】：博士
【學(xué)位授予年份】：2005
【分類(lèi)號(hào)】：R363

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