Background: After the establishment of relationship between angiogenesis and tumorgrowth by Folkman in1971, efforts are being made for treating cancer by targetingangiogenesis. Melanoma differentiation-associated-7（MDA-7） gene is a novel melanomadifferentiation associated gene that functions as a multi-modality anti-cancer agent.Manystudies have demonstrated it antiangiogenesis effect in different tumor models by variousroutes. Objective: The aim of this study to demonstrate its antiangiogene... 

【文章頁數(shù)】：37 頁

【學位級別】：碩士

【文章目錄】：
Abstract
Chapter 1 Introduction
Chapter 2 Literature Search
    2.1 Lymphoma And Angiogenesis
    2.2 MDA-7
    2.3 MICRO-VESSELS DENSITY
    2.4 CD31
Chapter 3 STUDY DESIGN
    3.1 PRINCIPLE
    3.2 MATERIALS AND METHODS
    3.3 Cell Culture
    3.4 Animal Experiments
    3.5 IVIS System
    3.6 Immunohistochemical examination
    3.7 Statistical analysis:
Chapter 4 RESULTS
    4.1 IL-24 protein secreted capacity of AAV8-MDA7/IL-24 vectors in vivo
    4.2 Establishment of lymphoma cells transplanted mouse model
    4.3 Suppression of tumor growth in lymphoma model mice after administrated AAV8-MDA7/IL-24
    4.4 Suppression of tumor microvessel density in AAV8-MDA7/IL- 24 administrated mice
Chapter 5 Discussion
Chapter 6 Significance of the study
Chapter 7 References
Chapter 8 Declarations
Chapter 9 Introduction To Author
ACKNOWLEDGEMENTS



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