脊髓α運(yùn)動神經(jīng)元直接支配骨骼肌活動,是軀體運(yùn)動和行為控制的最后公路（final common path）。因此,運(yùn)動神經(jīng)元興奮性調(diào)控對于運(yùn)動行為的執(zhí)行至關(guān)重要。事實(shí)上,脊髓運(yùn)動神經(jīng)元接受多種神經(jīng)調(diào)質(zhì)的傳入,尤其是單胺能神經(jīng)調(diào)質(zhì)。然而,組胺和下丘腦組胺能神經(jīng)系統(tǒng)對脊髓運(yùn)動神經(jīng)元的調(diào)控作用及其下游離子機(jī)制至今仍不清楚。本研究采用大鼠脊髓腦片細(xì)胞內(nèi)記錄方法,發(fā)現(xiàn)組胺H1和H2受體的激活均能增強(qiáng)脊髓α運(yùn)動神經(jīng)元的重復(fù)放電行為和興奮性。鉀通道的關(guān)閉和鈉-鈣交換體的激活共同參與了H1受體激活介導(dǎo)的脊髓運(yùn)動神經(jīng)元的興奮,而超極化激活的環(huán)核苷酸門控（hyperpolarizationactivated cyclic nucleotide-gated, HCN）通道的開放則負(fù)責(zé)H2受體激活介導(dǎo)的興奮性效應(yīng)。以上結(jié)果提示,通過切換與組胺受體相耦聯(lián)的離子通道和交換體的功能狀態(tài),組胺可以有效地偏置脊髓α運(yùn)動神經(jīng)元的興奮性,而下丘腦組胺能神經(jīng)傳入很可能以這種方式直接調(diào)控最終的運(yùn)動輸出并主動調(diào)節(jié)脊髓運(yùn)動反射和運(yùn)動執(zhí)行。 

【文章來源】：生理學(xué)報. 2019年06期 北大核心

【文章頁數(shù)】：15 頁

【文章目錄】：
1 MATERIALS AND METHODS
    1.1 Spinal slice preparations
    1.2 Intracellular recordings,motoneuron identification,drug application and data acquisition
    1.3 Statistics
2 RESULTS
    2.1 Histamine H1 and H2 receptors mediate the his- tamine-induced excitation in spinalα-motoneurons
    2.2 Activation of H1/H2 receptor increases intrinsic excitability of spinalα-motoneurons
    2.3 Activation of H1 receptor increases membrane resistance of spinalα-motoneurons
    2.4 Dual ionic mechanism mediates the depolariza-tion induced by activation of H1 receptor on spinalα-motoneurons
    2.5 Activation of H2 receptor decreases membrane resistance of spinalα-motoneurons
    2.6 Opening of HCN channels mediates the depo-larization induced by activation of H2 receptor on spinalα-motoneurons
3 DISCUSSION



本文編號：2918488