【摘要】：目的:對熱性中藥致虛熱證模型的復(fù)制和評價進(jìn)行探究。方法:使用不同劑量熱性中藥附子、干姜、肉桂灌胃大鼠。每天觀察大鼠的活動狀態(tài)、毛發(fā)光澤、爪色、二便等一般狀況,每天定時測定大鼠的肛溫、糞便量、尿液量、飲水量、飲食量,并于體液消耗量出現(xiàn)明顯差異時采集血液和相關(guān)組織器官,測定血清三碘甲狀腺原氨酸(T3),甲狀腺素(T4),血漿環(huán)磷酸腺苷(cAMP)及環(huán)磷酸鳥苷(cGMP)含量的變化和相關(guān)臟器指數(shù)。結(jié)果:與空白組比較,各模型組大鼠飲水量、體液消耗量大多數(shù)升高,動物出現(xiàn)虛熱證的證候;且血清中T4含量呈增高趨勢,T3/T4降低。模型低劑量組和模型中劑量組的cAMP和cGMP含量與空白組比較大多數(shù)顯著升高,而模型高劑量組含量則有所降低。結(jié)論:灌胃熱性中藥可以復(fù)制出虛熱證模型,體液消耗量的增加對虛熱證模型復(fù)制有一定的指導(dǎo)意義。
[Abstract]:Objective: to explore the replication and evaluation of heat deficiency syndrome model caused by heat traditional Chinese medicine (TCM). Methods: different doses of heat traditional Chinese medicine aconite, dried ginger and cinnamon were used intragastrically in rats. The activity, hair luster, claw color and second stool of the rats were observed every day. The anal temperature, fecal volume, urine volume, water consumption and food intake of the rats were measured regularly every day. Blood and related tissues and organs were collected when there was significant difference in body fluid consumption, and serum triiodothyronine (T3) and thyroxine (T4) were measured. Changes of plasma cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) content and related organ index. Results: compared with the blank group, most of the rats in each model group had higher drinking water and body fluid consumption, and the syndrome of deficiency heat syndrome appeared, and the content of T 4 in serum was increased and T3/T4 decreased. The contents of cAMP and cGMP in the low dose group and the middle dose group were significantly higher than those in the blank group, while those in the high dose group were lower than those in the blank group. Conclusion: traditional Chinese medicine can replicate the model of deficiency heat syndrome, and the increase of body fluid consumption has certain guiding significance for the replication of deficiency heat syndrome model.
【作者單位】： 江西中醫(yī)藥大學(xué);
【基金】：國家自然科學(xué)基金項(xiàng)目(81260642) 江西省研究生創(chuàng)新專項(xiàng)(YC2015-B066)
【分類號】：R285.5;R-332

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