【摘要】：目的通過模型加壓兔子腎臟,監(jiān)測(cè)加壓前后腎功能變化,論證壓力對(duì)腎功能的影響,根據(jù)實(shí)驗(yàn)結(jié)果給多囊腎臨床治療提供借鑒。方法將成年新西蘭兔隨機(jī)分為三組(A,B,C),A組兔子切除一側(cè)腎臟,另一側(cè)腎臟通過模型固定圓形氣泡予腎臟加壓;B組兔子切除一側(cè)腎臟,另一側(cè)腎臟通過模型固定塑料圓球予腎臟加壓;C組兔子切除一側(cè)腎臟,另一側(cè)腎臟不予加壓處理。分別監(jiān)測(cè)實(shí)驗(yàn)組和對(duì)照組兔子術(shù)前術(shù)后腎功的變化(血肌酐、尿素)。對(duì)不同加壓腎臟標(biāo)本進(jìn)行HE、masson和六氨銀染色,了解腎臟加壓后的病理改變。結(jié)果實(shí)驗(yàn)組A行加壓術(shù)后腎功相對(duì)術(shù)前與對(duì)照組C相比無明顯差異;實(shí)驗(yàn)組B行加壓術(shù)后,肌酐、尿素升高明顯,與術(shù)前、實(shí)驗(yàn)組A、對(duì)照組C比較均有明顯差異(P0.01)。實(shí)驗(yàn)組C一側(cè)腎切除后相比術(shù)前腎功能無明顯差異。病理示:腎臟加壓后,腎小球、腎小管、腎血管繼發(fā)一系列損害腎功的病理改變。結(jié)論對(duì)腎臟施加的壓力足夠大的時(shí)候,壓力致使腎臟發(fā)生相應(yīng)病理改變,肌酐、尿素升高,腎功能明顯下降。因此傳統(tǒng)的囊腫去頂減壓術(shù),仍是有意義的對(duì)癥治療手段。
[Abstract]:Aim to investigate the effect of pressure on renal function by monitoring the changes of renal function before and after compression in rabbits, and to provide a reference for clinical treatment of polycystic kidney according to the experimental results. Methods Adult New Zealand rabbits were randomly divided into three groups (A, B, C), A). One side of the kidney was resected in group B, and the other was compressed by fixed plastic spheres in group C, and the other kidney was not treated with pressure in group C. The changes of renal function (serum creatinine and urea) were monitored before and after operation in the experimental group and the control group respectively. Renal specimens under different pressures were stained with HE,masson and silver hexa-ammonia to understand the pathological changes after renal compression. Results there was no significant difference in renal function between experimental group A and control group C before and after operation, but in experimental group B, creatinine and urea increased significantly after operation, and there was significant difference between group A and control group C before and after operation (P0.01). The renal function of experimental group A and control group C were significantly higher than those of control group (P0.01). There was no significant difference in renal function before and after C side nephrectomy in the experimental group. Pathology: after renal compression, glomeruli, tubules, and renal vessels were secondary to a series of pathological changes that damaged renal function. Conclusion when the pressure on the kidney is high enough, the renal pathological changes occur, the creatinine and urea increase, and the renal function decreases obviously. Therefore, the traditional decompression of cyst decapitation is still a meaningful symptomatic treatment.
【學(xué)位授予單位】：第四軍醫(yī)大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2011
【分類號(hào)】：R-332

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相關(guān)期刊論文 前1條

1 歐平;鄧曉洪;鄭軍;王元中;;后腹腔鏡腎囊腫去頂減壓術(shù)治療成人多囊腎[J];重慶醫(yī)學(xué);2009年15期

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本文編號(hào)：2446421