【摘要】：第一部分 基于CT圖像的下頜骨髁突支架的個(gè)體化設(shè)計(jì) 研究目的 探索運(yùn)用醫(yī)學(xué)圖像處理和逆向工程技術(shù)相結(jié)合的方法來個(gè)體化設(shè)計(jì)下頜骨髁突支架負(fù)模,為組織工程構(gòu)建下頜骨髁突支架提供一種有效的技術(shù)手段。 研究方法 以CT掃描的影像資料作為數(shù)據(jù)源,利用Mimics軟件獲取一側(cè)下頜支形狀的數(shù)據(jù),并以.STL格式輸入到Solidworks軟件中進(jìn)行編輯,最終獲得下頜骨髁突支架的負(fù)型模具文件。 研究結(jié)果 1.一側(cè)下頜支三維模型的建立 將頭顱CT影像資料以DICOM格式輸入到三維重建軟件Mimics 8.1中,進(jìn)行閾值選取、區(qū)域增長(zhǎng)等操作,重建出一側(cè)下頜支三維模型,并以.STL格式輸出。 2.下頜骨髁突支架負(fù)型模具的生成 利用Solidworks 2010中的"scan to 3D"模塊來處理下頜支三維模型的網(wǎng)格數(shù)據(jù),最后生成實(shí)體模型。通過“型腔”命令來完成下頜骨髁突支架負(fù)模的構(gòu)建,通過“分割”命令將髁突支架負(fù)模切割為三部分,并以.STL格式輸出。 研究結(jié)論 基于頭顱CT影像資料,利用三維重建軟件Mimics 8.1獲得一側(cè)下頜支三維模型的網(wǎng)格數(shù)據(jù),再利用機(jī)械設(shè)計(jì)軟件Solidworks 2010對(duì)獲得的網(wǎng)格數(shù)據(jù)進(jìn)行整理、編輯,并獲取所需的三維特征曲線,最終通過三維曲面表達(dá)出下頜骨髁突負(fù)模的模具模型。 第二部分 基于快速成型技術(shù)的下頜骨髁突支架的初步構(gòu)建 研究目的 探討運(yùn)用快速成型技術(shù)與模具內(nèi)澆注的方法制造具有雙相支架復(fù)合材料的下頜骨髁突支架,為下頜骨髁突支架的生成提供一種方法。 研究方法 將Solidworks 2010中獲取的下頜骨髁突支架負(fù)模的模具文件輸入到objet studio軟件中,進(jìn)行模型的放置,調(diào)整好后發(fā)送到j(luò)ob manager中進(jìn)行三維打印,將得到的樹脂模具去除支撐材料得到實(shí)體模具,對(duì)模具進(jìn)行固定,下層澆注膠原材料,中層澆注PLGA,上層澆注磷酸鈣骨水泥和PLGA微球體。固化后去除樹脂模具得到雙相下頜骨髁突模型,通過掃描電鏡觀察其微觀結(jié)構(gòu)。 研究結(jié)果 通過快速成型技術(shù)獲得了下頜骨髁突支架負(fù)模的樹脂模型,通過生物材料澆注獲得了一體化的雙相下頜骨髁突支架結(jié)構(gòu)。通過電鏡掃描證實(shí)下頜骨髁突支架生物材料具有雙相結(jié)構(gòu)。 研究結(jié)論 快速成型技術(shù)與醫(yī)學(xué)影像技術(shù)、計(jì)算機(jī)輔助設(shè)計(jì)技術(shù)以及材料學(xué)等新興技術(shù)相結(jié)合,可以獲取并重建出下頜骨髁突的外部輪廓及其雙相結(jié)構(gòu),實(shí)現(xiàn)了下頜骨髁突支架制造的個(gè)體化,為骨組織工程更好地向臨床過渡奠定了基礎(chǔ)。
[Abstract]:Part one: individualized design of mandibular condylar stents based on CT images objective to explore the application of medical image processing and reverse engineering to individualize the design of mandibular condylar stents. To provide an effective technique for the construction of mandibular condylar scaffolds by tissue engineering. Methods the data of mandibular branch shape of one side were obtained by Mimics software with CT scanning image data as data source, and were input into Solidworks software with. STL format for editing. Finally, the negative mould file of mandibular condylar scaffold was obtained. Results 1. The 3D model of unilateral mandibular branch was established. The CT image data of one side of mandible were input into the 3D reconstruction software Mimics 8.1 in DICOM format, and the threshold was selected and the region was increased. The 3D model of mandibular branch of one side was reconstructed. And output in. STL format. 2. The generation of negative mold for mandibular condylar stents uses the "scan to 3D" module in Solidworks 2010 to process the mesh data of the mandibular branch 3D model, and finally to generate the solid model. The negative mold of the mandibular condyle is constructed by the "cavity" command, and the negative mold of the condylar stent is cut into three parts by the "split" command, which is output in the form of. STL. Conclusion based on the cranial CT image data, the 3D reconstruction software Mimics 8.1 was used to obtain the grid data of the mandibular branch 3D model, and the mechanical design software Solidworks 2010 was used to collate and edit the obtained grid data. Finally, the mold model of the negative model of the mandibular condyle is expressed by the 3D surface. Part two the preliminary construction of mandibular condylar scaffolds based on rapid prototyping objective to investigate the fabrication of composite materials with biphasic scaffolds using rapid prototyping and mold casting Mandibular condylar stents, To provide a method for the formation of mandibular condylar stents. Methods the mold file of the negative model of mandibular condyle bracket obtained from Solidworks 2010 was input into objet studio software, and then the model was placed, adjusted and sent to job manager for 3D printing. The solid mould was obtained by removing the supporting material from the resin mould, the mould was fixed, the lower layer was poured with collagen material, and the middle layer of PLGA, was poured into the upper layer of calcium phosphate cement and PLGA microsphere. A biphasic mandibular condyle model was obtained by removing the resin mould after curing and the microstructure of the model was observed by scanning electron microscope (SEM). Results the resin model of the mandibular condyle scaffold was obtained by rapid prototyping, and the biphasic mandibular condyle scaffold structure was obtained by biomaterial pouring. The biphasic structure of mandibular condylar scaffold was confirmed by electron microscope scanning. Conclusion the combination of rapid prototyping and medical imaging, computer-aided design, materials science and other emerging technologies can obtain and reconstruct the external contour and biphasic structure of mandibular condyle. The individualization of mandibular condyle scaffolds was realized, which laid the foundation for better transition of bone tissue engineering to clinical.
【學(xué)位授予單位】：復(fù)旦大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2011
【分類號(hào)】：R322

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