一株植物乳桿菌Lp3對高脂模型大鼠的益生作用
[Abstract]:[objective] to study the probiotic effect of a Lactobacillus plantarum Lp3 strain by establishing a rat hyperlipidemia model. [methods] Lactobacillus plantarum Lp3 was used to screen yak yoghurt from Qinghai-Tibet Plateau. It was preliminarily concluded that Lp3 was a cholesterol-lowering strain with good tolerance, and its probiotic characteristics were prominent in vitro. In this study, a rat model of high-fat SD was established. In order to determine the effect of Lactobacillus plantarum Lp3, on blood lipids, the effects of Lactobacillus plantarum Lp3, on intestinal flora, fecal moisture, cholesterol and bile acid in rats were studied. The results showed that Lactobacillus plantarum Lp3 had no obvious side effects on rats, and had a good effect on reducing blood lipid in hyperlipidemic rats. The serum total cholesterol of rats fed with high fat diet and fed with lactic acid bacteria (Lp3) group was compared with that of (HL) group. The contents of triglyceride and low density lipoprotein cholesterol were significantly lower than those of high fat diet group (P0.05), but the content of high density lipoprotein cholesterol did not change significantly. HC group, HL group and general diet group (control group). The number of Escherichia coli in feces of rats in HC group was significantly higher than that in control group. The number of Bifidobacterium and Lactobacillus decreased significantly. However, the number of lactobacillus in feces of HL group was slightly higher than that of control group, and the number of Escherichia coli and Bifidobacterium was basically the same as that of control group. The results showed that Lactobacillus plantarum Lp3 could maintain the balance of intestinal flora. In addition, the fecal water content of HL group was significantly higher than that of HC group compared with HC group (P0.05), indicating that Lp3 could reduce lipid deposition in liver tissue. Conclusion: the results showed that Lactobacillus plantarum Lp3 screened in this study had a prebiotic effect on hyperlipidemic rats.
【作者單位】: 蘭州大學(xué)生命科學(xué)學(xué)院草地農(nóng)業(yè)生態(tài)系統(tǒng)國家重點(diǎn)實(shí)驗(yàn)室;蘭州生物制品研究所;
【基金】:國家自然科學(xué)基金(31272486)~~
【分類號】:R-332;R589.2
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