【摘要】：目的:考察防己與茯苓配伍對(duì)脾虛水濕不化模型大鼠的影響。方法:采用高脂低蛋白飼料加力竭游泳的方法建立模型,通過(guò)檢測(cè)對(duì)胃腸功能、肝臟功能、血清蛋白和血脂水平的影響考察防己與茯苓組合對(duì)脾虛水濕不化模型大鼠的影響。結(jié)果:與模型組比較,防己水煎液組ALT、AST、TG、CHO和LDL-C顯著降低,HDL-C顯著升高;茯苓水煎液組Gas和ALB顯著升高,CHO和LDL-C顯著降低;防己低劑量+茯苓組Gas、ALB和HDL-C顯著升高(P0.05,P0.01),ALT、AST、TG、CHO和LDL-C顯著降低(P0.05,P0.01);防己中劑量+茯苓組Gas、TC、ALB和HDL-C顯著升高(P0.05,P0.01),ALT、AST、TG、CHO和LDL-C顯著降低(P0.05,P0.01);防己高劑量+茯苓組Gas、TC、TP、ALB和HDL-C顯著升高(P0.05,P0.01),ALT、AST、TG、ALP、CHO和LDL-C顯著降低(P0.05,P0.01)。結(jié)論:各給藥組對(duì)模型大鼠的胃腸、肝臟和血清學(xué)指標(biāo)均有改善,且兩藥配伍療效優(yōu)于單味藥。
[Abstract]:Objective: To investigate the effect of compatibility of Fangchi and Poria cocos on rats with spleen-deficiency and water-dampness.Methods: The model was established by exhaustive swimming with high-fat and low-protein diet. Results: Compared with the model group, ALT, AST, TG, CHO and LDL-C in Fangji Decoction group were significantly decreased, HDL-C was significantly increased; Gas and ALB in Fuling Decoction group were significantly increased, CHO and LDL-C were significantly decreased; Gas, ALB and HDL-C in Fangji low dose + Fuling group were significantly increased (P 0.05, P 0.01), ALT, AST, TG, CHO and LDL-C were significantly decreased (P 0.05, P 0.01); Ga, ALT, AST, TG, CHO and LDL-C in Fangji middle dose + Fuling group were significantly increased (P 0.05, P 0.01). S, TC, ALB and HDL-C were significantly increased (P 0.05, P 0.01), ALT, AST, TG, CHO and LDL-C were significantly decreased (P 0.05, P 0.01); Gas, TC, TP, ALB and HDL-C were significantly increased (P 0.05, P 0.01), ALT, AST, TG, ALP, CHO and LDL-C were significantly decreased (P 0.05, P 0.01) in Fangji high dose + Fuling group. The compatibility of two drugs is better than that of single medicine.
【作者單位】： 黑龍江中醫(yī)藥大學(xué);
【基金】：國(guó)家重點(diǎn)基礎(chǔ)研究發(fā)展計(jì)劃(973計(jì)劃)項(xiàng)目(No.2013CB531801)~~
【分類(lèi)號(hào)】：R285.5;R-332

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1 高潔;基于復(fù)合因素的大鼠脾虛水濕不化模型的建立與評(píng)價(jià)[D];山東中醫(yī)藥大學(xué);2015年

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