【摘要】：炎癥的啟動(dòng)、發(fā)展、消退是受到促炎性介質(zhì)及內(nèi)源性促消退介質(zhì)調(diào)控的一系列主動(dòng)過(guò)程。繼發(fā)現(xiàn)由花生四烯酸衍生的脂氧素及從炎癥消退階段的炎性滲出物中分離出由ω-3多不飽和脂肪酸轉(zhuǎn)化而來(lái)的消退素與保護(hù)素后,在自我消退炎性滲出物和脂質(zhì)調(diào)控介質(zhì)中最近發(fā)現(xiàn)了一個(gè)新的有效的抗炎家族稱為maresins。maresins由內(nèi)源性二十二碳六烯酸通過(guò)活化的巨噬細(xì)胞轉(zhuǎn)化而成,在參與組織內(nèi)環(huán)境平衡、炎癥消退、切口愈合和減輕疼痛、機(jī)體防御等方面發(fā)揮有益的作用。
[Abstract]:The initiation, development and regression of inflammation are a series of active processes regulated by proinflammatory mediators and endogenous mediators. After the discovery of lipoxygenin derived from arachidonic acid and the exudates from inflammatory exudates during the subsiding phase of inflammation, which were transformed by 蠅 -3 polyunsaturated fatty acids, A new effective anti-inflammatory family called maresins.maresins has recently been found in self-subsiding inflammatory exudates and lipid regulatory mediums, which is transformed by endogenous 22 carbohexaenoic acid through activated macrophages, and is involved in environmental balance in tissues. Inflammation subsided, wound healing and pain relief, body defense and other aspects play a useful role.
【作者單位】： 瀘州醫(yī)學(xué)院研究生院;瀘州醫(yī)學(xué)院附屬醫(yī)院內(nèi)分泌科;
【分類號(hào)】：R392

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1 陶慧嫻;吳升華;;消散素與保護(hù)素[J];生命的化學(xué);2009年04期

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本文編號(hào)：2141959