【摘要】：目的探究VEG株弓形蟲卵囊對(duì)中國(guó)昆明小鼠的致病性。方法分別選擇1個(gè),100個(gè)~108個(gè)的VEG株弓形蟲卵囊灌胃昆明小鼠,采用MAT、HE和IHC方法研究小鼠對(duì)弓形蟲的感染情況,并分析小鼠感染率,生存率及其大腦內(nèi)的弓形蟲包囊數(shù)量。結(jié)果≥10~2個(gè)VEG株弓形蟲卵囊可引起小鼠100%感染,最低致死劑量為10~2個(gè)卵囊,100%致死劑量為108個(gè)卵囊,急性期死亡時(shí)間為7DPI~14DPI,弓形蟲的成囊率是32.14%(9/28),包囊數(shù)量為9~857個(gè)/只小鼠大腦,感染小鼠生存率為67.44%(29/43),最長(zhǎng)存活時(shí)間≥390DPI。結(jié)論 VEG株弓形蟲卵囊對(duì)昆明小鼠的毒力中等,包囊形成率較高。
[Abstract]:Objective to investigate the pathogenicity of toxoplasma gondii oocysts of VEG strain on Kunming mice. Methods one or 100 ~ 108 VEG strains of Toxoplasma gondii oocysts were gavaged to Kunming mice. The infection rate, survival rate and the number of Toxoplasma gondii cyst in the brain were analyzed by MATHE-HE and IHC methods. Results Toxoplasma gondii oocysts of 鈮，

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