本文選題：小建中湯 + 胃潰瘍��； 參考：《山東中醫(yī)藥大學(xué)學(xué)報》2016年06期

【摘要】：目的:研究小建中湯配伍不同糖類方對胃潰瘍模型小鼠影響的差異及機制。方法 :根據(jù)灌胃無水乙醇法建立小鼠胃潰瘍模型,給模型小鼠連續(xù)灌藥7 d后眼球采血檢測血清SOD、MDA含量;采血后即處死小鼠,取全胃剖開測定潰瘍指數(shù),進(jìn)行肉眼胃黏膜形態(tài)學(xué)觀察,并行HE染色,顯微鏡觀察胃組織病理學(xué)變化。結(jié)果:小建中湯飴糖組、小建中湯葡萄糖組能明顯降低胃潰瘍模型小鼠的潰瘍指數(shù),降低潰瘍模型小鼠血清中MDA含量,提高SOD含量,與模型組比較存在顯著性差異,有統(tǒng)計學(xué)意義(P0.05);小建中湯白砂糖組、小建中湯乳糖組與模型組比較無顯著性差異。結(jié)論:小建中湯飴糖組、小建中湯葡萄糖組對無水乙醇法致小鼠胃潰瘍具有一定的預(yù)防和保護(hù)作用,其機制可能與其抑制體內(nèi)自由基生成、提高氧自由基清除系統(tǒng)活性等有關(guān)。
[Abstract]:Objective: to study the effect and mechanism of Xiaojianzhong decoction (XJD) combined with different carbohydrate prescriptions on gastric ulcer model mice. Methods: the gastric ulcer model of mice was established according to the method of gastric anhydrous ethanol. After 7 days of continuous administration of drugs, the serum levels of SOD MDA were measured in the eyeball of the model mice, and the mice were killed immediately after the blood collection, and the ulcer index was determined by total gastric dissection. The pathological changes of gastric mucosa were observed by microscope and HE staining. Results: Xiaojianzhong Tang caramel group and Xiaojianzhong decoction glucose group could significantly reduce the ulcer index, decrease the MDA content and increase the SOD content in the serum of the gastric ulcer model mice, and there was significant difference between the two groups. There was statistical significance (P0.05); there was no significant difference between the small Jianzhong decoction white sugar group and the lactose group and the model group. Conclusion: Xiaojianzhong Tang caramel group and Xiaojianzhong decoction glucose group have some preventive and protective effects on gastric ulcer induced by anhydrous ethanol in mice. The mechanism may be related to the inhibition of free radical formation in vivo and the enhancement of oxygen free radical scavenging system activity.
【作者單位】： 山東中醫(yī)藥大學(xué);
【基金】：山東省自然科學(xué)基金項目(編號:Z2010HQ028) 大學(xué)生研究訓(xùn)練計劃(SRT)(編號:2015027)
【分類號】：R285.5;R-332

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 吳亮生;劉永福;朱慶華;陳華;周云霄;劉國祥;陸明;丁一上;楊德林;;8310粉對大鼠胃潰瘍模型療效的組織學(xué)與組織化學(xué)觀察[J];石河子醫(yī)學(xué)院學(xué)報;1993年03期

2 魏丹丹;林海鳴;徐芳;王建芬;劉海燕;肖海英;;白及提取物對動物胃潰瘍模型的藥理研究[J];長沙醫(yī)學(xué)院學(xué)報;2014年02期

3 湯傳新;王士平;張洪泉;胡堅;;甘草鋅對動物胃潰瘍模型療效的組織學(xué)及組織化學(xué)觀察[J];新疆醫(yī)學(xué)院學(xué)報;1987年04期

4 劉宇峰;;中華胃康抗小鼠胃潰瘍作用的實驗研究[J];山西中醫(yī)學(xué)院學(xué)報;2009年03期

5 劉學(xué)榮, 王蓮蕓;抗?jié)⑸⒌膶嶒炑芯縖J];山西臨床醫(yī)藥;1995年03期

6 胡金芳;王春鳳;馮s，

本文編號：2104639