本文選題：心肌梗死 + 冠狀動(dòng)脈結(jié)扎　； 參考：《國(guó)際心血管病雜志》2016年02期

【摘要】：目的:比較兩種制作大鼠急性心肌梗死模型的冠狀動(dòng)脈結(jié)扎法,推薦一種穩(wěn)定性高、生存率高的模型制作方法。方法:將40只SD大鼠按照隨機(jī)數(shù)字法分為兩組:常規(guī)組和改進(jìn)組,比較兩組的手術(shù)時(shí)間、生存率,術(shù)后24h測(cè)量?jī)山M大鼠心肌梗死面積,危險(xiǎn)區(qū)面積以危險(xiǎn)區(qū)占左室面積的百分比(Ar/LV)表示,心肌梗死面積用梗死區(qū)占危險(xiǎn)區(qū)面積的百分比(An/Ar)表示,比較兩組Ar/LV和An/Ar。結(jié)果:術(shù)后3h改進(jìn)組和常規(guī)組的存活率分別為90%和60%,二者比較無(wú)統(tǒng)計(jì)學(xué)差異(P0.05);術(shù)后24h改進(jìn)組大鼠的存活率為85%,常規(guī)組為45%,兩組間有顯著的統(tǒng)計(jì)學(xué)差異(P0.05);常規(guī)組Ar/LV和An/Ar分別為51.4%±2.5%和52.5%±2.4%,改進(jìn)組Ar/LV和An/Ar分別為51.5%±2.3%和52.5%±2.2%,兩組間均無(wú)統(tǒng)計(jì)學(xué)差異(P0.05);常規(guī)組的操作時(shí)間明顯長(zhǎng)于改進(jìn)組,為(627.9±16.0)s對(duì)(253.9±12.7)s(P0.01)。結(jié)論:改進(jìn)的模型制作方法提高了大鼠生存率,縮短了手術(shù)時(shí)間,具有顯著優(yōu)越性,值得推廣。
[Abstract]:Aim: to compare the two methods of coronary artery ligation (CAL) in acute myocardial infarction (AMI) rats. Methods: forty Sprague-Dawley rats were randomly divided into two groups: routine group and improved group. The operation time, survival rate and myocardial infarction area were measured 24 hours after operation. The area of risk area was expressed as the percentage of risk area to left ventricular area (Ar-LV), and the area of myocardial infarction was expressed as the percentage of infarcted area to risk area (An/Ar). Results: the survival rates of the improved group and the routine group were 90% and 60%, respectively (P0.05), the survival rate of the improved group was 85% at 24 hours after operation, and that of the routine group was 45% (P0.05), and there was a significant difference between the two groups (P0.05). And An/Ar were 51.4% 鹵2.5% and 52.5% 鹵2.4% respectively. The Ar-LV and An/Ar of the improved group were 51.5% 鹵2.3% and 52.5% 鹵2.2%, respectively. There was no significant difference between the two groups (P0.05), the operation time of the routine group was significantly longer than that of the improved group. It was (627.9 鹵16.0) s pair (253.9 鹵12.7) s (P0.01). Conclusion: the improved model making method can improve the survival rate and shorten the operation time of rats. It has obvious advantages and is worth popularizing.
【作者單位】： 河南中醫(yī)學(xué)院第一附屬醫(yī)院心臟中心;河南中醫(yī)學(xué)院第一附屬醫(yī)院中心實(shí)驗(yàn)室;
【基金】：國(guó)家自然科學(xué)青年基金支持項(xiàng)目(81303073) 河南省科技攻關(guān)重點(diǎn)項(xiàng)目(112102310317) 河南省高�？萍紕�(chuàng)新團(tuán)隊(duì)支持計(jì)劃(13IRTSTHN012) 河南省中醫(yī)藥防治心血管疾病創(chuàng)新型科技團(tuán)隊(duì)(C20130050) 河南中醫(yī)學(xué)院省屬科研業(yè)務(wù)專項(xiàng)(2014KYYWF-YQ12);河南中醫(yī)學(xué)院一附院博士項(xiàng)目(2012KJ32)
【分類號(hào)】：R542.22;R-332

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