本文選題：丙酸睪酮 + 埋植劑��； 參考：《科學(xué)技術(shù)與工程》2017年09期

【摘要】：探討丙酸睪酮(丙睪)埋植劑在大鼠體內(nèi)的藥物釋放過程,建立釋放模型。將丙睪埋植劑分別包裝成2支和4支組,隨后將70只雄性Wistar大白鼠按體重隨機(jī)分為兩組,在兩組大鼠背部皮下分別植入2支和4支丙睪埋植劑。在丙睪埋植劑植入大白鼠體內(nèi)前0 d及植入后的1 d、3 d、7 d、14 d、30 d、60 d、90 d、180 d,采用斷尾方式采集2支組大鼠血樣1 mL,用睪酮放射免疫試劑盒檢測血清中睪酮含量。在埋植后的14 d、30 d、60 d、90 d、180 d將動物體內(nèi)的丙睪埋植劑取出,通過重量的差值計(jì)算藥物在體內(nèi)的釋放量。結(jié)果丙睪埋植劑在體內(nèi)的累積釋放量隨著埋植時(shí)間的延長呈逐漸上升趨勢。至180 d時(shí),兩組埋植劑內(nèi)藥物幾乎全部釋放出來。而體內(nèi)血清中睪酮濃度變化趨勢正好與體內(nèi)釋放量變化趨勢相反,隨著埋植天數(shù)的增加,睪酮濃度逐漸下降。經(jīng)過釋放模型驗(yàn)證,丙酸睪酮埋植劑體內(nèi)釋放遵循一級釋放方程。埋植劑中的丙睪可以通過硅膠囊管壁滲透出來,被吸收入血后,可使血清中睪酮濃度維持幾個(gè)月之久,可以認(rèn)為本埋植劑是一種能長期緩慢釋放丙睪藥物的控釋給藥系統(tǒng)。
[Abstract]:To investigate the drug release process of testosterone propionate (testosterone propionate) implant in rats and establish a release model. 70 male Wistar rats were randomly divided into two groups according to their body weight. Two and four clondymal implants were implanted subcutaneously on the back of the two groups. The blood samples of the two groups were collected for 180 days at the first 0 days before implantation and 1 day 3 days after implantation. The serum testosterone levels were detected by testosterone radioimmunoassay kit. The rats were divided into two groups: 1 mL of blood samples were collected by tail-amputated method and 30 days, 30 days, 60 days, 90 days and 90 days, 180 days after implantation, and the serum testosterone levels were detected by testosterone radioimmunoassay kit. After 14 days, 30 days, 60 days, 90 days, 180 days after implantation, the implant agent was taken out, and the amount of drug released in vivo was calculated by the difference of weight. Results the accumulative release amount of the implants increased gradually with the prolongation of implantation time. At 180 days, almost all of the drugs in the two groups were released. However, the change trend of serum testosterone concentration was opposite to that of body release amount, and the testosterone concentration decreased gradually with the increase of embedding days. The release of testosterone propionate in vivo followed the first-order release equation. After being absorbed into blood, the concentration of testosterone in serum can be maintained for several months. It can be considered that this implant is a controlled release drug delivery system which can slowly release propididymal drugs for a long time.
【作者單位】： 遼寧省計(jì)劃生育科學(xué)研究院;國家衛(wèi)生計(jì)生委生殖健康與遺傳醫(yī)學(xué)重點(diǎn)實(shí)驗(yàn)室;
【基金】：遼寧省自然科學(xué)基金(2013020170)資助
【分類號】：R965;R-332

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