本文選題：蛋白激酶C-γ + 長時(shí)程增強(qiáng)效應(yīng)�。� 參考：《中華眼科醫(yī)學(xué)雜志(電子版)》2016年01期

【摘要】：蛋白激酶C-γ是經(jīng)典型蛋白激酶C家族中的一個(gè)亞型。作為蛋白激酶C家族中的一員,它具有蛋白激酶C的普遍作用,同時(shí)又具有其特異作用。在磷脂酰絲氨酸存在的情況下,蛋白激酶C-γ可被Ca~(2+)、磷脂酰甘油等激活。蛋白激酶C-γ具有神經(jīng)特異性,主要在大腦皮層和脊髓的神經(jīng)元中表達(dá)。cPKC-γ的缺失或突變是導(dǎo)致許多神經(jīng)系統(tǒng)疾病的原因之一,可誘發(fā)原發(fā)性視網(wǎng)膜色素變性、白內(nèi)障和脊髓小腦共濟(jì)失調(diào)等疾病。異常視覺經(jīng)驗(yàn)可通過神經(jīng)發(fā)育可塑性影響視皮層發(fā)育最終導(dǎo)致弱視產(chǎn)生,作為一種神經(jīng)特異性蛋白激酶,c PKC-γ是否在視覺發(fā)育可塑性中發(fā)揮作用,仍存在爭議。本文中筆者主要從cPKC-γ的生物化學(xué)性質(zhì)、分子作用機(jī)制和與其相關(guān)的疾病方面進(jìn)行綜述。
[Abstract]:Protein kinase C-緯 is a subtype of classical protein kinase C family. As a member of protein kinase C family, protein kinase C has both universal and specific effects. In the presence of phosphatidyl serine, protein kinase C- 緯 can be activated by Ca ~ (2) and phosphatidylglycerol. Protein kinase C- 緯 (PKC- 緯) is neurospecific. The deletion or mutation of protein kinase C- 緯 in neurons of cerebral cortex and spinal cord is one of the causes of many nervous system diseases, which can induce primary retinitis pigmentosa. Cataract and spinal cerebellum ataxia and other diseases. Abnormal visual experience can affect the development of visual cortex through neurodevelopmental plasticity and lead to amblyopia. As a kind of neuro-specific protein kinase c PKC- 緯, it is still controversial whether PKC- 緯 plays a role in visual development plasticity. In this paper, the biochemical properties, molecular mechanism and related diseases of cPKC- 緯 are reviewed.
【作者單位】： 首都醫(yī)科大學(xué)附屬北京同仁醫(yī)院北京同仁眼科中心
【基金】：國家自然科學(xué)基金項(xiàng)目(No.30600688) 北京市自然科學(xué)基金項(xiàng)目(No.7132057) 北京市優(yōu)秀人才培養(yǎng)計(jì)劃項(xiàng)目(No.2010D003034000007)
【分類號(hào)】：R363

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