本文選題：超連續(xù)譜 + 激光光譜��； 參考：《光譜學(xué)與光譜分析》2017年02期

【摘要】：超連續(xù)譜激光指的是當(dāng)泵浦激光穿過(guò)特殊光波導(dǎo)時(shí),一系列的非線性效應(yīng)引起入射激光束的光譜展寬,從而輸出寬光譜激光束。隨著超快激光和光子晶體光纖技術(shù)的發(fā)展,利用超短脈沖在光子晶體光纖中的傳播鏈產(chǎn)生相干的且亮度高的超連續(xù)譜激光成為了一種理想的白光源。自從超連續(xù)譜激光源投入應(yīng)用以來(lái),其應(yīng)用領(lǐng)域越來(lái)越廣。尤其在生物醫(yī)學(xué)的細(xì)胞、血液等樣品分析當(dāng)中,熒光光譜學(xué)、流式細(xì)胞儀、共焦顯微、光學(xué)相干層析等技術(shù)都是強(qiáng)有力的分析工具,在采用這些先進(jìn)技術(shù)的科學(xué)儀器中,超連續(xù)譜激光源成為了一種主要光學(xué)部件。首先對(duì)超連續(xù)譜激光源的國(guó)際研究進(jìn)展作了詳細(xì)介紹,然后對(duì)超連續(xù)激光光譜技術(shù)在顯微成像、流式細(xì)胞儀、熒光壽命成像顯微、熒光共振能量轉(zhuǎn)移、光學(xué)相干層析、共焦顯微生物醫(yī)學(xué)分析等生物醫(yī)學(xué)領(lǐng)域中的發(fā)展及應(yīng)用作了綜合闡述。對(duì)超連續(xù)激光光譜技術(shù)在非接觸式血液制品鑒別的需求、方案及研究進(jìn)展進(jìn)行了重點(diǎn)論述,包括覆蓋400~2 000nm光譜范圍的光纖化輕型超連續(xù)譜激光光源研究;采用超連續(xù)譜激光光譜方法探索不同物種血液的種屬特征;根據(jù)大數(shù)據(jù)的血液樣品光譜特征元數(shù)據(jù)庫(kù)分析建立數(shù)學(xué)模型,利用數(shù)學(xué)模型實(shí)現(xiàn)對(duì)血液樣品種屬光譜學(xué)判定;血液鑒別光譜分析便攜式整機(jī)系統(tǒng)研發(fā)等。對(duì)超連續(xù)激光光譜技術(shù)在生物醫(yī)學(xué)領(lǐng)域的應(yīng)用前景作了展望。
[Abstract]:When the pump laser passes through a special optical waveguide, a series of nonlinear effects result in the spectral broadening of the incident laser beam and the output of the wide-spectrum laser beam. With the development of ultra-fast laser and photonic crystal fiber (PCF) technology, coherent and high-brightness supercontinuum laser using ultrashort pulse in photonic crystal fiber has become an ideal white light source. Since the superCW laser source has been put into use, its application field is more and more extensive. Especially in biomedical cell, blood and other sample analysis, fluorescence spectroscopy, flow cytometry, confocal microscopy, optical coherence chromatography and other techniques are powerful analytical tools. The supercontinuum laser source has become one of the main optical components. In this paper, the international research progress of supercontinuum laser sources is introduced in detail, and then the techniques of supercontinuum laser spectroscopy in microscopic imaging, flow cytometry, fluorescence lifetime imaging microscopy, fluorescence resonance energy transfer, optical coherence tomography are introduced in detail. The development and application of confocal microbiomedical analysis and other biomedical fields are reviewed. The requirement, scheme and research progress of supercontinuous laser spectroscopy in non-contact blood products identification are discussed in detail, including the study of optical fiber light supercontinuum laser light source covering 400 ~ 2 000nm spectrum range. The blood species characteristics of different species were explored by using supercontinuum laser spectroscopy, and the mathematical model was established according to the spectral characteristic meta-database of big data's blood samples, and the spectral identification of blood samples was realized by using the mathematical model. Research and Development of Portable whole Machine system for Blood Identification Spectroscopy. The prospect of the application of supercontinuous laser spectroscopy in biomedicine is also discussed.
【作者單位】： 中國(guó)科學(xué)院空間主動(dòng)光電技術(shù)重點(diǎn)實(shí)驗(yàn)室;
【基金】：國(guó)家高技術(shù)研究發(fā)展計(jì)劃863項(xiàng)目(2015AA021103) 國(guó)家自然科學(xué)基金項(xiàng)目(81260225) 中國(guó)科學(xué)院重點(diǎn)實(shí)驗(yàn)室基金項(xiàng)目(CXJJ-14-S134);中國(guó)科學(xué)院“百人計(jì)劃”擇優(yōu)項(xiàng)目資助
【分類號(hào)】：R312;TN24

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