本文選題：通絡(luò)救腦口服液 + 淀粉樣蛋白β��； 參考：《中藥新藥與臨床藥理》2016年04期

【摘要】：目的探討通絡(luò)救腦口服液對(duì)快速老化模型(SAMP8)小鼠晚期糖基化終末產(chǎn)物受體(RAGE)和淀粉樣蛋白β(Aβ)表達(dá)的影響。方法 24只SAMP8小鼠隨機(jī)分為模型組、通絡(luò)救腦高、低劑量組(9,6 m L·kg~(-1)·d~(-1)),另設(shè)抗快速衰老亞系1(SAMR1)小鼠對(duì)照組(正常對(duì)照組),連續(xù)灌胃給藥21 d。取海馬區(qū)腦組織,分別采用酶聯(lián)免疫吸附法(ELISA)和免疫組織化學(xué)法檢測(cè)小鼠大腦海馬內(nèi)Aβ以及RAGE的表達(dá)。結(jié)果與模型組比較,通絡(luò)救腦高、低劑量組海馬區(qū)腦組織RAGE和Aβ表達(dá)降低(P0.01),RAGE蛋白含量明顯降低(P0.01)。結(jié)論通絡(luò)救腦口服液可通過抑制海馬區(qū)腦組織RAGE和Aβ的表達(dá),以減輕RAGE和Aβ介導(dǎo)的神經(jīng)病理?yè)p傷作用。
[Abstract]:Objective to investigate the effect of Tongluojionao oral liquid on the expression of advanced glycosylation end product receptor (RAGEG) and amyloid 尾 -butadiene (A 尾) in mice with rapid aging model (SAMP8). Methods Twenty-four SAMP8 mice were randomly divided into two groups: model group, Tongluo Jiao Gao group, low dose group, 9m L / kg ~ (-1) D ~ (-1) ~ (-1) D ~ (-1), and control group (normal control group, n = 21) with anti-aging subline 1 ~ (1) SAM ~ (1) (control group), which were given intragastric administration continuously for 21 days. The expressions of A 尾 and RAGE in hippocampus of mice were detected by Elisa and immunohistochemistry. Results compared with the model group, the expression of RAGE and A 尾 in the hippocampus of the low dose group was significantly lower than that in the model group. Conclusion Tongluojionao Oral liquid can attenuate the neuropathological injury mediated by RAGE and A 尾 by inhibiting the expression of RAGE and A 尾 in hippocampus.
【作者單位】： 河南中醫(yī)藥大學(xué);天津中醫(yī)藥大學(xué);
【基金】：國(guó)家自然科學(xué)基金青年基金項(xiàng)目(81303088) 河南省科技廳基礎(chǔ)與前沿科研項(xiàng)目(142300410171)
【分類號(hào)】：R285.5;R-332
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本文編號(hào)：1968243