本文選題：解郁安神方 + 慢性溫和應激��； 參考：《中國臨床藥理學雜志》2017年16期

【摘要】：目的研究解郁安神方對慢性溫和應激(CMS)抑郁動物模型學習記憶功能的影響。方法按照體重將成年雄性昆明小鼠隨機分為5組(每組6只):空白組,模型組,大中小3個劑量實驗組(解郁安神方,50,100,200 mg·kg~(-1))。制備CMS抑郁大鼠模型。用Morris水迷宮(MWM)評價實驗動物空間學習記憶功能。結果給藥后第4天,模型組與小中大3個劑量實驗組平臺潛伏期分別是(42.33±7.76)s與(27.83±6.34),(17.00±6.42),(12.67±5.28)s,與模型組比較,3個劑量實驗組差異均有統(tǒng)計學意義(均P0.05),提示解郁安神方醇提物可改善CMS抑郁動物模型學習功能。給藥后第5天,模型組與大劑量實驗組平臺象限潛伏期分別是(48.67±13.37),(24.33±15.33)s,與模型組比較,大劑量實驗組差異有統(tǒng)計學意義(P0.05)。模型組與中大2個劑量實驗組平臺象限時間分別是(38.17±11.36)s與(64.17±8.84),(65.00±9.75)s,與模型組比較,2個劑量實驗組差異均有統(tǒng)計學意義(均P0.05),提示解郁安神方醇提物可改善CMS抑郁動物模型記憶功能。結論解郁安神方可以影響CMS抑郁動物模型MWM定位航行訓練與空間探索測試不同階段行為學變化,提示其可改善CMS抑郁動物模型學習記憶功能。
[Abstract]:Objective to study the effect of Jieyu Anshen recipe on learning and memory function of chronic mild stress depression animal model. Methods the adult male Kunming mice were randomly divided into 5 groups according to their body weight (6 mice in each group: blank group, model group, 3 experimental groups with large, medium and small doses) (Jieyu Anshen decoction 50100200 mg / kg). CMS depression rat model was established. The spatial learning and memory function of experimental animals was evaluated by Morris water maze. Results on the 4th day after administration, The plateau latencies of the model group and the small, medium and large dose groups were 42.33 鹵7.76 and 27.83 鹵6.34, respectively. Compared with the model group, the differences among the three dose groups were statistically significant (P 0.05), suggesting that the alcohol extract of Jieyu Anshen prescription could improve the learning function of CMS depression animal model. On the 5th day after administration, the latencies of platform quadrant in the model group and the experimental group were 48.67 鹵13.37 and 24.33 鹵15.33 seconds, respectively. Compared with the model group, there was significant difference between the high dose group and the experimental group (P 0.05). The time of platform quadrant in the model group and the middle and large dose groups were 38.17 鹵11.36s and 64.17 鹵8.84 respectively. Compared with the model group, the differences between the two groups were statistically significant (P 0.05), suggesting that the alcohol extract of Jieyu Anshen prescription could improve the memory function of CMS depression animal model. Conclusion Jieyu Anshen prescription can affect the behavioral changes of MWM positioning navigation training and space exploration test in CMS depression animal model, suggesting that it can improve the learning and memory function of CMS depression animal model.
【作者單位】： 新鄉(xiāng)醫(yī)學院第二附屬醫(yī)院藥學部;山東中醫(yī)藥大學第二附屬醫(yī)院山東省中西醫(yī)結合醫(yī)院;
【基金】：國家自然科學基金青年基金資助項目(81302887) 山東省科技發(fā)展計劃基金資助項目(2014GSF119034) 山東省中醫(yī)藥科技發(fā)展計劃基金資助項目(2015-131) 山東省醫(yī)務職工科技創(chuàng)新基金資助項目(魯醫(yī)工字[2015]33號)
【分類號】：R285.5;R-332

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