本文選題：脊柱側(cè)凸 + 瘦素�。� 參考：《南京大學(xué)》2012年博士論文

【摘要】：第一章雙足直立小鼠模型高中樞瘦素水平對(duì)脊柱側(cè)凸影響研究 目的：研究中樞高瘦素水平對(duì)雙足直立鼠模型脊柱側(cè)凸發(fā)生率及嚴(yán)重程度的影響,從動(dòng)物實(shí)驗(yàn)層次上驗(yàn)證脊柱側(cè)凸中樞高瘦素水平假說。 方法：選取3周齡雌性C3He/ej小鼠50只,于麻醉狀態(tài)下切除小鼠前肢及尾部,建立雙足直立鼠模型。建模成功后三天,將雙足直立小鼠模型隨機(jī)分成兩組：一組通過顱內(nèi)注射方式將瘦素過表達(dá)慢病毒載體注入小鼠下丘腦,建立中樞高瘦素水平雙足直立鼠模型；另一種則通過顱內(nèi)注射方式將空白慢病毒載體注入小鼠下丘腦,建立對(duì)照雙足直立鼠模型。兩組小鼠模型均于相同條件下飼養(yǎng)于鼠籠中并通過高位飲食誘導(dǎo)其直立體態(tài)。成功建模20周后,通過X-ray評(píng)估兩組小鼠模型脊柱側(cè)凸發(fā)生率及嚴(yán)重程度。然后處死小鼠取外周血液樣本,通過ELISA試劑盒評(píng)估兩組小鼠外周血中瘦素水平。 結(jié)果：本研究結(jié)果顯示中樞高瘦素水平組雙足直立小鼠外周瘦素水平明顯高于對(duì)照組(p0.05),但中樞高瘦素水平組體重較對(duì)照組雖有所減少,但未見顯著差異(p0.05)。影像學(xué)結(jié)果顯示25只中樞高瘦索水平組雙足直立鼠中23只發(fā)生脊柱側(cè)凸,平均Cobb角29.9°,而對(duì)照組25只小鼠中只有13只發(fā)生脊柱側(cè)凸,平均Cobb角18.3°。上述結(jié)果顯示中樞高瘦素水平組小鼠脊柱側(cè)凸發(fā)生率明顯高于對(duì)照組。而發(fā)生脊柱側(cè)凸的小鼠中,中樞高瘦素水平組小鼠模型脊柱側(cè)凸平均Cobb角顯著高于對(duì)照組。 結(jié)論：本研究結(jié)果顯示中樞高瘦素水平不僅能夠提高雙足直立小鼠脊柱側(cè)凸發(fā)生率,而且可能引起脊柱側(cè)凸進(jìn)一步進(jìn)展,提示中樞高瘦素水平可能是導(dǎo)致脊柱側(cè)凸發(fā)生的重要影響因素。 第二章(第一節(jié))青少年特發(fā)性脊柱側(cè)凸患者小腦扁桃體位置與后顱窩容積間相關(guān)性研究 目的：本研究通過磁共振(Magnetic Resonance Imaging, MRI)測(cè)量特發(fā)性脊柱側(cè)凸(Idiopathic Scoliosis, IS)患者與年齡匹配正常對(duì)照后顱窩各骨性標(biāo)志間線性距離,比較兩組后顱窩容積差異,并分析IS患者后顱窩發(fā)育異常與小腦扁桃體生理性下疝間相關(guān)性。 方法：從2009年1月至2011年6月我科收治500例IS患者中選取研究對(duì)象,入選標(biāo)準(zhǔn)為：(1)患者年齡16-20歲,Risser征均為5級(jí)。(2)患者術(shù)前行站立位全脊柱正側(cè)位X線片及頸枕部MRI檢查。選取年齡匹配正常對(duì)照組。測(cè)量?jī)山M研究對(duì)象頭頸正中矢狀位MRI中小腦扁桃體下緣超出BO線的距離(d值),枕骨大孔徑(AB),斜坡長(zhǎng)度(AD),枕上長(zhǎng)度(BC)以及后顱窩矢狀徑(CD)等指標(biāo),比較兩組小腦扁桃體位置及后顱窩容積差異。然后根據(jù)MRI影像學(xué)表現(xiàn),再將IS患者按照是否伴發(fā)生理性小腦扁桃體下疝進(jìn)行分組,分析后顱窩容積與小腦扁桃體生理性下疝間關(guān)系及主彎Cobb角與小腦扁桃體生理性下疝程度間相關(guān)性。 結(jié)果：IS患者共70例,平均年齡17.2±1.5歲,男48例(68.6%),女22例(31.2%),平均Cobb角51.2土14.1。。對(duì)照組共58例,平均年齡17.3±1.4歲,男27例,女31例。研究結(jié)果顯示IS患者的小腦扁桃體下緣超出BO線的距離(d值)明顯大于正常對(duì)照組(p=0.009),其生理性小腦扁桃體下疝發(fā)生率為22.9%。IS患者枕骨大孔徑明顯大于正常對(duì)照組(p0.001),而斜坡長(zhǎng)度(AD),枕上長(zhǎng)度(BC)以及后顱窩矢狀徑(CD)均明顯小于正常對(duì)照組(p0.001)。此外,IS患者d值與主彎Cobb角無顯著相關(guān)性(p=0.585)。生理性下疝組IS患者枕上長(zhǎng)度(BC)長(zhǎng)度顯著小于對(duì)照IS患者(p=0.008),而其他三項(xiàng)后顱窩線性指標(biāo)兩組間均未見顯著性差異。 結(jié)論：IS患者小腦扁桃體位置明顯低于正常青少年,生理性小腦扁桃體下疝發(fā)生率為22.9%,這可能是由于IS患者后顱窩枕骨大孔增大而斜坡、枕骨發(fā)育受限有關(guān),其病理機(jī)制尚需進(jìn)一步研究探討,提示IS患者顱骨發(fā)育過程中也存在成骨異常。 第二章(第二節(jié))Chiari畸形伴脊柱側(cè)凸患者后顱窩線性容積研究 目的：本研究通過MRI測(cè)量Chiari畸形Ⅰ型(Chiari Malformation Type Ⅰ, CMI)患者與年齡匹配正常青少年后顱窩各骨性標(biāo)志間線性距離,比較兩組后顱窩容積差異,分析CMI患者后顱窩容積與小腦扁桃體下疝程度及脊髓空洞間相關(guān)性。 方法：患者選自2003年至2010年CMI患者,入選標(biāo)準(zhǔn)為：(1)年齡16-20歲,Risser征5級(jí)。(2)經(jīng)頭頸部MRI確診為Chiari畸形Ⅰ型伴或不伴脊髓空洞。入選CMI患者均排除可致繼發(fā)性CMI及顱骨破壞相關(guān)疾病。選取年齡匹配正常青少年作為對(duì)照組。測(cè)量?jī)山M研究對(duì)象頭頸正中矢狀位MRI中枕骨大孔徑(AB),斜坡長(zhǎng)度(AD),枕上長(zhǎng)度(BC)以及后顱窩矢狀徑(CD)等指標(biāo),并將兩組按性別分組后比較后顱窩容積差異。根據(jù)MRI影像學(xué)表現(xiàn),將CMI患者按照小腦扁桃體下疝嚴(yán)重程度及是否伴發(fā)脊髓空洞進(jìn)行分組,分析后顱窩容積與小腦扁桃體下疝程度及脊髓空洞間關(guān)系。 結(jié)果：本研究中CMI患者共37例,平均年齡17.2歲,其中男23例(62.2%),女14例(37.8%)。對(duì)照組青少年共49例,平均年齡17.5歲,其中男24例(49.0%),女25例(51.0%)。結(jié)果顯示CMI患者后顱窩各骨性標(biāo)志間線性距離均明顯小于同性別、年齡匹配對(duì)照組青少年。此外,本研究還發(fā)現(xiàn)Ⅰ度扁桃體下疝CMI患者斜坡長(zhǎng)度(AD)明顯大于Ⅱ、Ⅲ度扁桃體下疝CMI患者,余指標(biāo)未見明顯差異。CMI伴脊髓空洞患者與單純CMI患者后顱窩各骨性標(biāo)志間線性距離亦未見顯著性差異。 結(jié)論：本研究顯示CMI患者存在明顯的顱骨發(fā)育障礙,支持了CMI是由中胚層旁葉發(fā)育受限所致這一假說。此外,本研究還發(fā)現(xiàn)斜坡發(fā)育受限可能是促使CMI患者小腦扁桃體下疝加重的重要因素之一,而顱骨發(fā)育受限并非脊髓空洞的主要致病因素。 第二章(第三節(jié))兒童Chiari畸形伴脊柱側(cè)凸的影像學(xué)特點(diǎn)與臨床意義 目的：通過對(duì)于Chiari畸形伴脊柱側(cè)凸患兒的臨床及影像學(xué)特征進(jìn)行研究,探討其臨床意義。 方法：研究對(duì)象選自2001年7月至2008年12月在我院就診的兒童(年齡10歲)Chiari畸形伴脊柱側(cè)凸患者。通過分析其臨床及影像學(xué)資料,測(cè)量胸椎后凸、腰椎前凸、MRI上小腦扁桃體下疝程度、空洞形態(tài)和長(zhǎng)度以及空洞與脊髓的最大比值(S/C最大比值),對(duì)以上測(cè)量指標(biāo)進(jìn)行比較分析。 結(jié)果：共有患兒40例入選,其中男23例(57.5%),女17例(42.5%)。本組患兒中累及胸彎37例(92.5%),單胸腰彎2例(5%),單腰彎1例(2.5%),不典型側(cè)凸的發(fā)生率47.5%(19/40例),其中左胸彎的發(fā)生率為22.5%(9/40例)。典型側(cè)凸模式中不典型特征發(fā)生率為72.7%(16/21例)。胸椎后凸角平均25.40,胸椎正常后凸與過度后凸占總患者的60%,腰椎前凸角平均53.1°,MRI發(fā)現(xiàn)其中36例(90%)伴有脊髓空洞。 結(jié)論：兒童Chiari畸形患者以胸彎累及多見,不典型彎型及典型彎型中不典型特征較多見,胸椎后凸角較大,對(duì)于具有上述特征的低齡脊柱側(cè)凸患兒,建議行全脊柱MRI排除神經(jīng)系統(tǒng)異常。 第二章(第四節(jié))Chairi畸形脊髓空洞枕大孔減壓術(shù)后脊髓空洞的自然轉(zhuǎn)歸 目的：研究?jī)和疌hiari畸形伴脊柱側(cè)凸患者接受枕骨大孔減壓術(shù)(PFD)術(shù)后脊髓空洞的自然轉(zhuǎn)歸,探索脊髓空洞PFD術(shù)后轉(zhuǎn)歸的相關(guān)影響因素。 方法：研究對(duì)象選自2000至2009年于本院接受PFD術(shù)的Chiari畸形伴脊髓空洞合并脊柱側(cè)凸患者。入選標(biāo)準(zhǔn)為：(1)患者年齡均小于或等于18歲；(2)經(jīng)MRI確診為Chiari畸形伴脊髓空洞；(3)以脊柱側(cè)凸為首診主訴；(4)入選患者均接受術(shù)前及術(shù)后MRI隨訪進(jìn)行評(píng)估Chiari畸形及脊髓空洞狀態(tài)。此外,本研究入選對(duì)象均排除繼發(fā)性Chiari畸形或接受脊髓空洞引流術(shù)的可能。本研究采用最大脊髓空洞/脊髓比(S/C ratio)及脊髓空洞長(zhǎng)度作為評(píng)估術(shù)前及術(shù)后隨訪脊髓空洞狀況的影像學(xué)指標(biāo)。根據(jù)末次術(shù)后隨訪資料,脊髓空洞S/C ratio或長(zhǎng)度較術(shù)前減少超過20%定義為脊髓空洞明顯緩解,而脊髓空洞完全消失則定義為脊髓空洞完全緩解。 結(jié)果：共有44例患者入選本研究。44例患者術(shù)前及術(shù)后6月均接受MRI檢查。其中37例患者術(shù)后2年接受MRI隨訪,26例患者術(shù)后4年接受MRI隨訪,15例患者術(shù)后6年接受MRI隨訪。根據(jù)末次隨訪MRI影像學(xué)資料,97.7%(43/44)的患者PFD術(shù)后脊髓空洞明顯緩解。本研究結(jié)果顯示小腦扁桃體下疝距離(mm)與PFD術(shù)對(duì)脊髓空洞的療效間存在顯著相關(guān)性(r=0.116,p=0.013)。同時(shí)我們發(fā)現(xiàn)脊髓空洞PFD術(shù)后緩解主要發(fā)生在術(shù)后6月內(nèi),6月之后脊髓空洞緩解雖然仍持續(xù)進(jìn)行,但是緩解速度明顯減低。 結(jié)論：絕大多數(shù)Chiari畸形伴脊髓空洞合并脊柱側(cè)凸患者接受枕骨大孔減壓術(shù)術(shù)后脊髓空洞顯著改善。而這種脊髓空洞的顯著改善主要發(fā)生在枕骨大孔減壓術(shù)術(shù)后6月內(nèi),其后脊髓空洞緩緩改善。同時(shí)我們發(fā)現(xiàn)小腦扁桃體下疝嚴(yán)重程度可能是影響枕骨大孔減壓術(shù)對(duì)脊髓空洞療效的重要潛在因素。
[Abstract]:Chapter 1 the influence of high level PIP leptin level on scoliosis in bipedal erect mouse model
Objective: To investigate the effect of high leptin levels on the incidence and severity of scoliosis in the bipedal erect rat model, and to verify the hypothesis of the high leptin level in the scoliosis center from the animal experimental level.
Methods: 50 female C3He/ej mice of 3 weeks old were selected to excision the forelimb and tail of mice under anesthesia. The model of bipedal erect rat was established. After three days of successful modeling, the model of bipedal erect mice was randomly divided into two groups: a group of leptin overexpressed lentivirus vectors were injected into the hypothalamus of mice by intracerebral injection, and the central leptin was established. The other one was injected into the hypothalamus of mice by injecting the blank lentivirus vector into the hypothalamus by intracerebral injection. The two groups of mice were fed in the cage and induced their erect posture under the same condition. After 20 weeks of successful modeling, the model of two groups of mice was evaluated by X-ray. The incidence and severity of scoliosis were observed. Then the mice were sacrificed and peripheral blood samples were taken to evaluate the level of leptin in peripheral blood of two groups of mice by ELISA kit.
Results: the results of this study showed that the peripheral leptin level in the central high leptin level group was significantly higher than that of the control group (P0.05), but the weight of the central leptin group was less than the control group, but there was no significant difference (P0.05). The imaging results showed that 23 of the 25 central high leptin groups had spinal lateral scoliosis rats. The average Cobb angle was 29.9 degrees, while only 13 of the 25 mice in the control group had scoliosis, with an average Cobb angle of 18.3 degrees. The results showed that the incidence of scoliosis in the central high leptin level group was significantly higher than that in the control group. In the mice with scoliosis, the average Cobb angle in the central high leptin level mice model scoliosis was significantly higher than that of the central high leptin level mice. Control group.
Conclusion: the results of this study show that the high leptin level can not only improve the incidence of scoliosis in bipedal erect mice, but also may cause further progress in scoliosis, suggesting that the level of high leptin may be an important factor in the incidence of scoliosis.
The second chapter (Section 1) correlation between cerebellar tonsil location and posterior fossa volume in adolescent idiopathic scoliosis
Objective: to measure the linear distance between the patients with idiopathic scoliosis (Idiopathic Scoliosis (IS) and the age-matched normal control posterior fossa bone markers by Magnetic Resonance Imaging (MRI), to compare the volume difference between the two groups of posterior cranial fossa, and to analyze the abnormal development of posterior fossa in IS patients and the physiological hernia of the tonsil of the cerebellum. Inter correlation.
Methods: from January 2009 to June 2011, 500 patients with IS were selected and selected. The criteria were: (1) the age of the patients was 16-20 years old, and the Risser sign was 5. (2) the patients were performed the normal lateral X-ray of the spine and the cervical occipital MRI before operation. The age matched normal control group was selected. The two groups of subjects were measured in the head and neck sagittal sagittal. The location of the two cerebellar tonsils and the volume difference between the posterior cranial fossa and the two groups of cerebellar tonsils were compared with the distance (D value), the large aperture (AB), the length of the occipital bone (AD), the length of the occipital (BC) and the sagittal diameter (CD) of the posterior fossa. Then, according to the imaging findings of the MRI, the patients with the cerebellar tonsil hernia were followed by the MRI imaging. The relationship between posterior cranial fossa volume and physiological lower hernia of cerebellar tonsil was analyzed, and the correlation between the Cobb angle of main bend and the degree of physiological herniation in cerebellar tonsil was analyzed.
Results: a total of 70 IS patients, the average age of 17.2 + 1.5 years, 48 men (68.6%), 22 women (31.2%), and the average Cobb angle 51.2 soil 14.1.. Control group were 58, the average age 17.3 + 1.4 years, male 27, and 31 cases. The results showed that the distance of the lower margin of the cerebellar tonsil of the IS patients (D value) was significantly greater than the normal control group (p=0.009), and its physiological characteristics were small. The large pore size of the occipital bone in 22.9%.IS patients was significantly greater than that of the normal control group (p0.001), while the slope length (AD), the length of the occipital (BC) and the posterior fossa sagittal diameter (CD) were significantly smaller than those of the normal control group (p0.001). Besides, there was no significant correlation between the D value of the IS patients and the main bend Cobb angle (p=0.585). The length of the occipital pillow in the physiological hernia group was on the occipital length. (BC) the length was significantly less than that of the control IS patients (p=0.008), while the other three posterior cranial fossa linear indices showed no significant difference between the two groups.
Conclusion: the position of cerebellar tonsil in IS patients is significantly lower than that of normal adolescents. The incidence of lower hernia is 22.9% in the physiological cerebellar tonsillar, which may be due to the enlargement of the occipital foramen in the posterior fossa of the IS patients and the restriction of the occipital bone development. The pathological mechanism of the occipital bone is still needed to be further studied. It is suggested that the osteogenesis in the development of the skull in the IS patients also exists in the process of osteogenesis. Often.
Second chapter (second). Posterior cranial fossa linear volume in patients with Chiari malformation associated with scoliosis
Objective: to measure the linear distance between the patients with Chiari malformation (Chiari Malformation Type I, CMI) and the posterior fossa bone markers of the age matched normal adolescents by MRI, the volume difference between the two groups of posterior cranial fossa was compared, and the correlation between the posterior cranial fossa volume and the degree of inferior hernia of the cerebellar tonsil and the cavities in the spinal cord of the cerebellar tonsil was analyzed.
Methods: the patients were selected from 2003 to 2010 CMI. The criteria were: (1) age 16-20, Risser sign 5. (2) Chiari malformation was diagnosed as type I with or without cavities in the head and neck. All CMI patients were excluded from secondary CMI and skull damage related diseases. Age matched normal adolescents were selected as control group. Two groups were measured. Two groups were measured. The large pore size (AB) of occipital bone (AD), the length of the occipital (BC) and the posterior fossa sagittal diameter (CD) in the median sagittal MRI of the head and neck were compared, and the difference of the volume of the posterior fossa was compared between the two groups according to sex. According to the MRI imaging findings, the severity of the hernia under the cerebellar tonsil and the concomitant cavities of the spinal cord were carried out in the CMI patients. The relationships between posterior cranial fossa volume and cerebellar tonsillar hernia and spinal cavity were analyzed.
Results: in this study, there were 37 cases of CMI patients, with an average age of 17.2 years old, including 23 men (62.2%) and 14 women (37.8%). The control group was 49 cases, with an average age of 17.5 years old, including 24 men (49%) and 25 (51%). The results showed that the linear distance between the bone markers in the posterior cranial fossa of CMI patients was significantly smaller than that of the same sex, age matched control group. In addition, the study also found that the slope length (AD) of CMI patients with I tonsillar hernia was significantly greater than that of II, and there was no significant difference in the residual index of CMI patients with lower hernia in the third degree tonsillar. There was no significant difference in the linear distance between the patients with.CMI with the cavities of the spinal cord and the posterior cranial fossa of the simple CMI patients.
Conclusion: This study shows that CMI patients have obvious cranial dysplasia and support the hypothesis that CMI is due to the limitation of mesoderm development. Furthermore, this study also found that the limitation of development of the clivus may be one of the important factors contributing to the aggravation of the cerebellar tonsil hernia in CMI patients, and the limitation of the skull development is not the main cause of the cavities in the spinal cord. Disease factors.
The second chapter (third). The imaging features and clinical significance of Chiari malformation associated with scoliosis in children
Objective: To study the clinical and imaging features of children with Chiari malformation associated with scoliosis and to explore its clinical significance.
Methods: the subjects were selected from July 2001 to December 2008 in our hospital (10 years old) with Chiari malformation with scoliosis. Their clinical and imaging data were analyzed to measure the degree of hernia under the thoracic kyphosis, lumbar lordosis, MRI cerebellar tonsillar, cavity shape and length, and the maximum ratio of cavities to the spinal cord (S/C max). Comparison and analysis of the above measurement indexes.
Results: a total of 40 children were selected, including 23 males (57.5%) and 17 females (42.5%), including 37 thoracic bending (92.5%), 2 single thoracolumbar bending (5%), 1 cases (2.5%) of single lumbar bend (2.5%), and the incidence of atypical scoliosis (19/40 cases), among which the incidence of left chest bending was 22.5% (9/40). The incidence of atypical characteristics in typical scoliosis mode was 57.5% (16/21 The posterior convex angle of the thoracic vertebra was 25.40, the normal kyphosis and the overprotruding of the thoracic vertebrae accounted for 60% of the total, and the average lumbar anterior convex angle was 53.1 degrees. MRI found that 36 cases (90%) were accompanied by cavities in the spinal cord.
Conclusion: the patients with Chiari malformation are frequently involved in thoracic curvature. The atypical characteristics of the atypical bending and typical curved types are more common, and the posterior convex angle of the thoracic vertebrae is large. It is suggested that the whole spinal column MRI exclude the abnormal nervous system for the children with the above characteristics of the age of the scoliosis.
The second chapter (fourth). The natural outcome of syringomyelia after decompression of foramen magnum in Chairi malformation.
Objective: To study the natural outcome of the cavities of the spinal cord after the operation of the occipital foramen magnum decompression (PFD) for children with Chiari malformation and scoliosis, and to explore the related factors of the outcome after the operation of the spinal cord cavity PFD.
Methods: the subjects were selected from 2000 to 2009 with Chiari malformation with spinal cord cavities with scoliosis in our hospital. The criteria were: (1) the age of the patients was less than or equal to 18 years old; (2) MRI was diagnosed as Chiari malformation with spinal cavities; (3) scoliosis was the primary complaint; (4) all patients received preoperative and postoperative surgery. MRI was followed up to assess the status of Chiari malformation and spinal cavity. In addition, this study excluded the possibility of secondary Chiari malformation or spinal cavity drainage. The present study used the maximum spinal cord / spinal cord ratio (S/C ratio) and the length of the spinal cord as an imaging index to evaluate the status of the cavities in the spinal cord before and after the operation. According to the follow-up data after the last operation, the S/C ratio or length of the spinal cavity was defined as the obvious relief of the cavities in the spinal cord, while the complete disappearance of the spinal cavity was defined as complete remission of the cavities in the spinal cord.
Results: a total of 44 patients were enrolled in the study,.44 patients received MRI examination before and after operation in June. Of them, 37 patients received MRI follow-up 2 years after operation, 26 patients received MRI follow-up 4 years after operation, 15 patients received MRI follow-up after 6 years. According to the last follow-up of MRI imaging data, 97.7% (43/44) patients were obviously relieved of cavities in spinal cord after PFD operation. The results of this study showed a significant correlation between the cerebellar tonsillar hernia distance (mm) and the effect of PFD on the cavities of the spinal cord (r=0.116, p=0.013). Meanwhile, we found that the remission of the spinal cavity after PFD was mainly in June after the operation, and the remission of the spinal cord was still continued after June, but the remission rate was significantly reduced.
Conclusion: most of the patients with Chiari malformation with scoliosis with scoliosis were significantly improved after the occipital decompression of the occipital foramen. The significant improvement in the cavities of the spinal cord mainly occurred within June after the occipital decompression of the occipital orifice, followed by the gradual improvement of the cavities in the spinal cord, and we found the severity of the cerebellar tonsil hernia. It may be an important potential factor affecting the effect of foramen magnum decompression on the cavity of spinal cord.

【學(xué)位授予單位】：南京大學(xué)
【學(xué)位級(jí)別】：博士
【學(xué)位授予年份】：2012
【分類號(hào)】：R682.3;R-332

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 朱鋒,邱勇,鄭曉剛,王斌,俞楊,朱澤章,孫桂勤;青少年特發(fā)性脊柱側(cè)凸患者脊柱前后柱生長(zhǎng)軟骨的超微結(jié)構(gòu)研究[J];電子顯微學(xué)報(bào);2004年01期

2 朱澤章,邱勇;脊髓空洞與脊柱側(cè)凸[J];脊柱外科雜志;2004年05期

3 王振福,李振芝,王曉華,潘之清;Chiari Ⅰ畸形的后顱窩磁共振測(cè)量研究[J];現(xiàn)代康復(fù);2001年06期

4 邱勇,朱麗華,宋知非,駱東山;脊柱側(cè)凸的臨床病因?qū)W分類研究[J];中華骨科雜志;2000年05期

5 邱勇,王斌,朱澤章,呂錦瑜,俞楊,朱麗華;脊柱側(cè)凸伴發(fā)Chiari畸形和(或)脊髓空洞的手術(shù)治療[J];中華骨科雜志;2003年09期

6 朱澤章,邱勇,王斌,俞楊,李衛(wèi)國(guó),朱麗華;青少年特發(fā)性脊柱側(cè)凸的支具治療[J];中華骨科雜志;2004年05期

7 朱鋒,邱勇,楊曉恩,李廣文,秦嶺,鄭振耀;青少年特發(fā)性和先天性脊柱側(cè)凸患者的骨微結(jié)構(gòu)及骨密度比較[J];中華骨科雜志;2005年09期

8 張?jiān)趶?qiáng),李新鋼,黃齊兵,張?jiān)i,宮崧峰;Chiari-I畸形并脊髓空洞癥247例外科治療[J];中華外科雜志;2004年19期

9 朱鋒,邱勇,孟魁,鄭振耀;青少年特發(fā)性脊柱側(cè)凸脊柱前后柱骨骺軟骨細(xì)胞的增殖和凋亡[J];中華外科雜志;2004年20期

10 孫旭;朱澤章;王斌;邱勇;;Chiari畸形和(或)脊髓空洞合并脊柱側(cè)凸的臨床特征[J];中華外科雜志;2007年08期

，

本文編號(hào)：1839596