本文選題：microRNA + mRNA�。� 參考：《山東醫(yī)藥》2017年30期

【摘要】：microRNA(miRNA)是一類單鏈非編碼小RNA,主要參與功能基因的轉(zhuǎn)錄后調(diào)控,具有廣泛、多樣的生物功能,在真核生物體內(nèi)對基因表達具有重要的調(diào)控作用。miRNA既可以抑制編碼基因mRNA的表達,又可以激活mRNA的作用;既可以在細胞質(zhì)中作用于mRNA的不同區(qū)域,也可以返回細胞核中發(fā)揮重要的生物學(xué)功能;同一個miRNA不一定只是一種作用模式,它可以同時作用于3'UTR、5'UTR和ORF區(qū)域。在細胞質(zhì)中,miRNA通過與mRNA 3個區(qū)域中存在的識別位點互補配對并結(jié)合一些輔助蛋白發(fā)揮作用;在細胞核中,miRNA通過與lncRNA的相互作用起到調(diào)節(jié)基因功能的作用;miRNA還可與DNA的啟動子序列相結(jié)合,誘導(dǎo)基因轉(zhuǎn)錄與翻譯。
[Abstract]:MicroRNAs miRNAs are a class of single-stranded non-coding small RNAs, which are mainly involved in the posttranscriptional regulation of functional genes, and have a wide range of biological functions. MiRNAs can inhibit the expression of the encoding gene mRNA in eukaryotic organisms. It can also activate the role of mRNA; it can act on different regions of mRNA in the cytoplasm, but also can return to the nucleus to play important biological functions. The same miRNA is not necessarily just a mode of action. It can act on both UTR and ORF region. In the cytoplasm, miRNAs work by complementing the recognition sites in the three regions of mRNA and binding to some coproteins. In the nucleus, miRNAs can regulate gene function by interacting with lncRNA, and can also bind to the promoter sequence of DNA to induce gene transcription and translation.
【作者單位】： 中國人民解放軍第82醫(yī)院;
【分類號】：R3416
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本文編號：1780672