本文選題：γ-氨基丁酸(GABA) + 大分子��； 參考：《波譜學(xué)雜志》2016年04期

【摘要】：J差分譜編輯技術(shù)已廣泛用于人腦g-氨基丁酸(γ-amino butyric acid,GABA)的檢測(cè),利用MEGA-PRESS序列可以有效編輯GABA在δ_H 3.02處的信號(hào).由于相近的化學(xué)位移和J耦合作用,大分子(macromolecule,MM)在δ_H 3.00的信號(hào)也同時(shí)被編輯,因此測(cè)量得到的GABA信號(hào)中包含一部分MM信號(hào)(GABA+MM,簡(jiǎn)稱(chēng)GABA+).對(duì)稱(chēng)譜編輯技術(shù)可以有效抑制大分子,但該方法對(duì)編輯脈沖的頻率選擇性要求較高,因此對(duì)稱(chēng)譜編輯技術(shù)中編輯脈沖持續(xù)時(shí)間一般較長(zhǎng).該研究將MEGA-PRESS序列中編輯脈沖持續(xù)時(shí)間由14 ms增加到20 ms,回波時(shí)間(echo time,TE)由68 ms增加到80 ms,分別測(cè)量GABA+與對(duì)稱(chēng)譜編輯技術(shù)抑制大分子后的GABA(簡(jiǎn)稱(chēng)GABA).結(jié)果發(fā)現(xiàn),在較長(zhǎng)編輯脈沖作用時(shí)間和較長(zhǎng)TE條件下,GABA比GABA+含量低27%;長(zhǎng)編輯脈沖持續(xù)時(shí)間可以有效提高編輯脈沖的頻率選擇性,更好地實(shí)現(xiàn)對(duì)稱(chēng)譜編輯技術(shù)抑制大分子,有助于分析人腦GABA含量測(cè)定中大分子信號(hào)干擾的影響.純GABA含量測(cè)量,有助于更準(zhǔn)確地分析GABA在人腦中的代謝過(guò)程,以及GABA含量與各種疾病和功能認(rèn)知反應(yīng)之間的相關(guān)性.
[Abstract]:J differential spectrum editing technique has been widely used in the detection of gamma-amino butyric acid (GABA) in human brain. The signal of GABA at 未 H 3.02 can be edited effectively by using MEGA-PRESS sequence. Because of the similar chemical shift and J coupling, the signal of macromolecule macromolecule MMM is edited at the same time. Therefore, the measured GABA signal contains a part of MM signal GABA-MMM, which is referred to as GABA-MMM. Symmetric spectrum editing technique can restrain macromolecules effectively, but this method requires high frequency selectivity of editing pulse, so the duration of editing pulse is generally longer in symmetrical spectrum editing technology. In this study, the duration of editing pulse in MEGA-PRESS sequence was increased from 14 Ms to 20 Ms, and echo time of echo time was increased from 68 Ms to 80 Ms. The GABA and symmetric spectrum editing techniques were used to measure GABA and symmetry spectrum editing technique respectively. The results showed that the content of GABA was 27% lower than that of GABA under the condition of longer pulse action time and longer te, the frequency selectivity of editing pulse could be improved effectively, and the technique of symmetrical spectrum editing could restrain macromolecules. It is helpful to analyze the influence of macromolecular signal interference in the determination of GABA content in human brain. The measurement of pure GABA content is helpful to more accurately analyze the metabolic process of GABA in human brain and the correlation between GABA content and various diseases and functional cognitive responses.
【作者單位】： 華東師范大學(xué)物理系上海市磁共振重點(diǎn)實(shí)驗(yàn)室;
【基金】：國(guó)家自然科學(xué)基金資助項(xiàng)目(81271533) 國(guó)家社科基金重大課題(15ZDB016)
【分類(lèi)號(hào)】：R338;O482.531

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