本文選題：放射性肺損傷 + 右全肺照射�。� 參考：《哈爾濱醫(yī)科大學學報》2011年02期

【摘要】：目的探討建立符合臨床實際情況的慢性放射性肺損傷動物模型的可行性。方法新西蘭白兔28只隨機分為右全肺照射組、雙肺照射組和對照組,照射組按SAD定角等中心照射技術照射建立放射性肺損傷動物模型,照射后第1、2、4、8、12、16周分別行CT及病理學檢查。結果照射4周內,右全肺照射組及雙肺照射組均有實驗動物死亡,CT及病理學檢查符合急性放射性肺炎,照射后8~12周CT可見毛玻璃樣征象,斑片狀及纖維索條影,病理學檢查示肺泡壁增厚呈纖維化改變。結論按SAD定角等中心方法建立了慢性放射性肺損傷的動物模型。
[Abstract]:Objective to investigate the feasibility of establishing chronic radiation lung injury animal model.Methods Twenty-eight New Zealand white rabbits were randomly divided into three groups: right lung irradiation group, double lung irradiation group and control group. The radiation group was irradiated with SAD isocentric irradiation technique to establish the animal model of radiation lung injury. Ct and pathological examination were performed at the 1st week after irradiation.Results within 4 weeks of irradiation, all the experimental animals in the right whole lung irradiation group and the double lung irradiation group had the experimental animal death CT and pathological examination accord with acute radiation pneumonitis, 812 weeks after irradiation, the signs of ground-glass, plaques and fibrous cord shadow could be seen on CT at 812 weeks after irradiation.Pathological examination showed that the alveolar wall thickened and showed fibrosis.Conclusion the animal model of chronic radiation-induced lung injury was established according to the central method of SAD.
【作者單位】： 桂林醫(yī)學院附屬醫(yī)院心胸外科;桂林醫(yī)學院附屬醫(yī)院放療科;桂林醫(yī)學院附屬醫(yī)院病理科;
【基金】：廣西醫(yī)療衛(wèi)生重點科研課題(重200981)
【分類號】：R734.2

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