本文選題：病理性鈣化　切入點(diǎn)：紅外光譜　出處：《巖石礦物學(xué)雜志》2017年06期

【摘要】：選取人體心臟瓣膜、動脈、甲狀腺、卵巢和乳腺5大類典型病理性鈣化共38例樣品開展了系統(tǒng)的紅外光譜表征,重點(diǎn)探討了樣品內(nèi)碳羥磷灰石(CHA)中CO2-3含量及CO2-3的取代類型特征。研究發(fā)現(xiàn),這5類典型病理性鈣化產(chǎn)物均以碳羥磷灰石為主要物相,相同部位鈣化物中的CO2-3含量基本保持一致,但不同部位鈣化物中的CO2-3平均含量差別較明顯,甲狀腺、乳腺中CO2-3平均含量最低,為6.2%,相比CO2-3平均含量最高的心臟瓣膜,相差3.3%。5類樣品含有的碳羥磷灰石均以B型取代(CO2-3取代PO3-4)為主,伴隨有少量A型取代(CO2-3取代OH-),鈣化物中的CO2-3含量與B/A取代比值的正向聯(lián)系不明顯。
[Abstract]:A total of 38 human heart valves, arteries, thyroid, ovarian and mammary gland samples of typical pathological calcifications were systematically characterized by infrared spectroscopy. The content of CO2-3 and the type of substitution of CO2-3 in the samples were discussed.It was found that the five typical pathological calcification products were carbon-hydroxyapatite as the main phase, and the CO2-3 content in the same calcification was basically the same, but the average content of CO2-3 in different calcifications was significantly different, thyroid gland, thyroid gland, thyroid gland, thyroid gland, thyroid gland, thyroid gland, thyroid gland, thyroid gland, thyroid gland, thyroid gland, thyroid gland, thyroid gland,The average content of CO2-3 in breast was the lowest (6.2%). Compared with the heart valve with the highest average content of CO2-3, there was a 3.3% difference between the carbon hydroxyapatite and B type hydroxyapatite (type B instead of CO2-3 instead of PO3-4).With a small amount of type A substituted CO2-3 substituted OH-O, the positive correlation between the CO2-3 content and the ratio of B / A substitution in calcified compounds was not obvious.
【作者單位】： 礦物環(huán)境功能北京市重點(diǎn)實(shí)驗(yàn)室北京大學(xué);北京大學(xué)醫(yī)學(xué)部基礎(chǔ)醫(yī)學(xué)院病理學(xué)系;北京醫(yī)院病理科;北京醫(yī)院心內(nèi)科;
【基金】：“973”計劃(2014CB846001) 國家自然科學(xué)基金(41230103,41522201)~~
【分類號】：R36

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1 李建輝;彭心宇;;病理性鈣化的生物學(xué)機(jī)制[J];農(nóng)墾醫(yī)學(xué);2006年03期

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