本文選題：抗衰老　切入點：秀麗隱桿線蟲　出處：《中國美容醫(yī)學》2016年02期

【摘要】：秀麗隱桿線蟲(Caenorhabditis elegans)是抗衰老研究中重要的模式生物之一,被廣泛應用于抗衰老物質的篩選和抗衰老分子機制的研究中。本文回顧了近年來秀麗隱桿線蟲在抗衰老領域應用的研究進展,介紹了抗衰老物質的篩選情況,系統(tǒng)綜述了作為抗衰老物質篩選評價的生理指標和反映抗衰老機制的生化指標包括壽命、生存率、生存時間、ROS含量、脂褐質積累以及daf-16,sod-3,gst-4,hsps基因調控情況等,指出了研究中存在的問題,展望了秀麗隱桿線蟲在抗衰老研究中的應用前景。
[Abstract]:Caenorhabditis eleanss (Caenorhabditis eleanss) is one of the most important model organisms in the study of anti-aging, and has been widely used in the screening of anti-aging substances and the study of anti-aging molecular mechanism.In this paper, the research progress of the application of Rhizoma elegans in the field of anti-aging in recent years was reviewed, and the screening of anti-aging substances was introduced.The physiological indexes, including life span, survival rate, Ros content, lipofuscin accumulation and the regulation of daf-16 sod-3gst-4hsps gene, were systematically reviewed as the physiological indexes for screening and evaluation of anti-aging substances and the biochemical indexes reflecting the anti-aging mechanism, such as life span, survival rate, Ros content, lipofuscin accumulation and daf-16 sod-3gst-4hsps gene regulation.The problems existed in the research were pointed out, and the application prospect of Steenostrongylus elegans in anti-aging research was prospected.
【作者單位】： 淮南聯(lián)合大學醫(yī)學系;淮南師范學院化學與材料工程學院;
【基金】：安徽省高校自然科學重點研究項目(KJ2015A349) 安徽省高校質量工程項目(2014jyxm472)
【分類號】：R339.38
，

本文編號：1718276