本文選題：血瘀證目征　切入點(diǎn)：球結(jié)膜微循環(huán)　出處：《南昌大學(xué)》2012年碩士論文

【摘要】：目的：研究五種不同血瘀證亞型目征改變的特點(diǎn)及其與血小板活化功能及炎癥損傷的關(guān)系。 方法：將60只健康日本大耳兔按隨機(jī)分組法分為6組，分別為氣虛血瘀組、氣滯血瘀組、寒凝血瘀組、熱毒血瘀組、外傷血瘀組、正常對(duì)照組進(jìn)行造模。比較各組血瘀證目征改變及積分的變化、同時(shí)觀測(cè)各組球結(jié)膜微循環(huán)、血清血小板膜糖蛋白P-選擇素(CD62P)、腫瘤壞死因子-α（TNF-a）水平的變化。 結(jié)果：(1)造模前各組血瘀證目征積分無(wú)顯著差異(P0.05)；(2)造模后血瘀證目征積分各模型組與正常對(duì)照組及各自造模前相比均有統(tǒng)計(jì)學(xué)意義(P0.05)；(3)治療后，血瘀證目征積分血瘀證各亞型組與各自造模后相比均有統(tǒng)計(jì)學(xué)意義(P0.05)。(4)造模前各組血清CD62P，TNF-a的水平無(wú)顯著差異(P0.05)；(5)造模后血清CD62P，TNF-a水平各模型組與正常對(duì)照組及各自造模前相比，具有顯著性差異(P0.01)；(6)治療后，，血清CD62P，TNF-a水平血瘀證各亞型組與各自造模后相比，具有顯著性差異(P0.01)；(7)造模后氣滯血瘀組CD62P明顯高于其他亞型組，熱毒血瘀組TNF-a明顯高于其他亞型組，差異均有統(tǒng)計(jì)學(xué)意義（P0.05）。 結(jié)論：血瘀證目征積分是診斷血瘀證的有效方法，但目征總積分并不能用于區(qū)別血瘀證不同亞型，需要借助血瘀證目征具體形態(tài)變化及各亞型不同的病理表現(xiàn)及球結(jié)膜微循環(huán)改變進(jìn)行綜合判斷。血瘀證各亞型之間有明確的血瘀證共性，但又各具特點(diǎn)。
[Abstract]:Objective: to study the characteristics of five subtypes of blood stasis syndrome and their relationship with platelet activation function and inflammatory injury. Methods: sixty healthy Japanese rabbits were randomly divided into 6 groups: Qi deficiency and blood stasis group, Qi stagnation and blood stasis group, cold coagulation and blood stasis group, heat toxin and blood stasis group, and traumatic blood stasis group. The changes of ocular sign and integral of blood stasis syndrome in each group were compared, and the changes of bulbar conjunctival microcirculation, serum platelet membrane glycoprotein (P-selectin) CD62PU and tumor necrosis factor- 偽 (TNF-a) were observed in normal control group. Results (1) there was no significant difference in the score of blood stasis syndromes in each group before and after modeling (P 0.05). There was statistical significance after treatment in each model group compared with the normal control group and the control group. There was no significant difference in serum CD62PtTNF-a levels before and after model making between each model group and each model group. The serum CD62PU TNF-a level in each model group was higher than that in the normal control group and before the model making, and there was no significant difference between each model group and the normal control group before and before the establishment of the model, and there was no significant difference in the serum CD62PU TNF-a level between the model group and the normal control group. After treatment, the levels of serum CD62PnTF-a in blood stasis syndrome group were significantly different from those after model making. (P 0.01) the CD62P of Qi stagnation and blood stasis group was significantly higher than that of other subtype group, and the TNF-a of heat toxin blood stasis group was significantly higher than that of other subtype group. The difference was statistically significant (P 0.05). Conclusion: the integral of eye sign of blood stasis syndrome is an effective method for diagnosis of blood stasis syndrome, but the total integral of eye sign can not be used to distinguish different subtypes of blood stasis syndrome. It is necessary to make a comprehensive judgment with the specific morphological changes of the eye signs of blood stasis syndrome, the different pathological manifestations of each subtype and the changes of bulbar conjunctiva microcirculation. There are definite similarities of blood stasis syndrome among the subtypes of blood stasis syndrome, but each has its own characteristics.
【學(xué)位授予單位】：南昌大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類號(hào)】：R363

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