本文選題：基因表達(dá)　切入點(diǎn)：轉(zhuǎn)錄延伸　出處：《中國(guó)免疫學(xué)雜志》2017年08期 　論文類型：期刊論文

【摘要】：基因轉(zhuǎn)錄是一個(gè)有序的多步驟過程,包括轉(zhuǎn)錄起始前、轉(zhuǎn)錄起始和轉(zhuǎn)錄延伸等幾個(gè)階段。長(zhǎng)期以來,轉(zhuǎn)錄起始前及轉(zhuǎn)錄起始階段調(diào)控一直被認(rèn)為是基因轉(zhuǎn)錄的關(guān)鍵限速步驟。然而,近年來利用全基因組深度測(cè)序等新技術(shù)對(duì)轉(zhuǎn)錄過程的深入研究,發(fā)現(xiàn)轉(zhuǎn)錄起始后的轉(zhuǎn)錄延伸階段也是許多基因表達(dá)調(diào)控的關(guān)鍵步驟,并且這種調(diào)控機(jī)制在從果蠅到哺乳動(dòng)物的不同物種之間高度保守。本文綜述了NELF、DSIF和P-TEFb等主要轉(zhuǎn)錄延伸調(diào)控因子調(diào)控RNA聚合酶Ⅱ轉(zhuǎn)錄暫停和高效轉(zhuǎn)錄延伸最新分子機(jī)制,并討論了轉(zhuǎn)錄延伸調(diào)控在癌癥、炎癥以及病毒感染等疾病發(fā)生中的作用。
[Abstract]:Gene transcription is an orderly multistep process that includes several stages, including pre-transcriptional initiation, transcriptional initiation and transcriptional extension. The regulation of pretranscriptional and transcriptional initiation stages has been considered to be a key rate-limiting step in gene transcription. However, in recent years, novel techniques such as full-genome deep sequencing have been used to further study the transcription process. It has been found that the transcriptional extension after transcription initiation is also a key step in the regulation of many genes expression. This regulation mechanism is highly conserved in different species from Drosophila to mammal. This paper reviews the latest molecular mechanisms of RNA polymerase 鈪，

本文編號(hào)：1643686