本文選題：參竹精片　切入點(diǎn)：骨質(zhì)疏松癥　出處：《中藥藥理與臨床》2017年01期 　論文類型：期刊論文

【摘要】：目的:觀察參竹精片對(duì)骨質(zhì)疏松癥大鼠脛骨密度及病理形態(tài)的影響。方法 :采用手術(shù)摘除大鼠雙側(cè)卵巢建立骨質(zhì)疏松癥模型,用參竹精片灌胃治療30天,測(cè)量脛骨重量/體積比、骨密度(BV)、骨小梁數(shù)量(TB.N)、骨小梁厚度(Tb.Th)、骨小梁分離度(Tb.Sp)及骨連接密度(Conn.D);測(cè)定血清骨鈣素(OC)和ALP濃度;觀察脛骨病理變化。結(jié)果:參竹精片360 mg/kg、180mg/kg、90mg/kg三個(gè)劑量治療組大鼠脛骨重量/體積比均明顯增加(模型組,1.36±0.07 g/cm~3;參竹精片分別為1.65±0.07g/cm~3,1.61±0.06g/cm~3,1.65±0.06 g/cm~3;BV明顯增加(模型組,933.88±8.97 mg AHccm;參竹精片360 mg/kg、90mg/kg劑量組分別為959.29±5.76 mg AHccm和966.39±5.51mg AHccm;血清OC濃度明顯增加(模型組205.91±11.46 pg/ml;參竹精片180mg/kg、90mg/kg劑量組分別為308.40±47.80 pg/ml和350.32±45.25 pg/ml;ALP濃度降低(模型組55.79±12.42 ng/ml;參竹精片360mg/kg、90mg/kg劑量組分別為41.34±12.50 ng/ml和40.89±12.92ng/ml;脛骨骨質(zhì)結(jié)構(gòu)緊密,密度增加,裂紋明顯減少。結(jié)論:參竹精片可增加骨密度,改善骨結(jié)構(gòu),對(duì)骨質(zhì)疏松癥具有一定治療作用。
[Abstract]:Objective: To observe shengzhujing tablets on osteoporosis rat tibial bone density and pathological morphology. Methods: the surgical removal of both ovaries of rats to establish the model of osteoporosis with shengzhujing tablets orally for 30 days, measure tibia weight / volume ratio, bone mineral density (BV), trabecular bone volume (TB.N) Liang Houdu (Tb.Th), trabecular bone, trabecular separation (Tb.Sp) and connectivity density (Conn.D); Determination of Serum Osteocalcin (OC) and ALP concentration; observation of pathological changes. Results: shengzhujing tablets 360 mg/kg, three 180mg/kg, 90mg/kg dose for the treatment of tibial weight / rats the volume ratio were significantly increased in the model group, (1.36 + 0.07 g/cm~3; shengzhujing tablets were 1.65 + 0.07g/cm~3,1.61 + 0.06g/cm~3,1.65 + 0.06 g/cm~3; BV was significantly increased in the model group, (933.88 + 8.97 mg AHccm; shengzhujing tablets 360 mg/kg, 90mg/kg dose group were 959.29 + 5.76 and 966.39 + 5.51mg AHccm mg AHccm blood; Serum OC concentration significantly increased in model group (205.91 + 11.46 pg/ml; shengzhujing tablets 180mg/kg, 90mg/kg dose group were 308.40 + 47.80 and 350.32 + 45.25 pg/ml pg/ml; the concentration of ALP decreased in model group (55.79 + 12.42 ng/ml; shengzhujing tablets 360mg/kg, 90mg/kg dose group were 41.34 + 12.50 and 40.89 + 12.92ng/ml ng/ml tibial; bone structure closely, increased the density of crack decreased significantly. Conclusion: shengzhujing tablets can increase bone density, improve the bone structure, has a certain effect on the treatment of osteoporosis.

【作者單位】： 天津中醫(yī)藥大學(xué)中醫(yī)藥研究院;
【基金】：教育部"創(chuàng)新團(tuán)隊(duì)發(fā)展計(jì)劃"(NO.IRT1276)
【分類號(hào)】：R285.5;R-332

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1 柳占彪;樊官偉;王歡歡;羅毅楊;高笑雨;張少卓;;參竹精片對(duì)骨質(zhì)疏松癥模型大鼠脛骨密度及病理形態(tài)的影響[J];中藥藥理與臨床;2017年01期

2 朱靜棟;孔西建;吳丹;李盈盈;葉進(jìn);毛春煥;王咪娜;王t樍，

本文編號(hào)：1578956