本文關(guān)鍵詞： 濃香型白酒 大鼠 血脂 脂代謝　出處：《現(xiàn)代預(yù)防醫(yī)學(xué)》2017年22期 　論文類型：期刊論文

【摘要】：目的觀察2種濃香型白酒對(duì)大鼠血脂及脂代謝關(guān)鍵酶的影響,分析不同酒樣對(duì)脂代謝影響的差異,探討適量飲酒調(diào)節(jié)機(jī)體脂代謝的可能機(jī)制。方法 105只雄性SD大鼠隨機(jī)分為7組,分別為1-1、1-2、1-3、2-1、2-2、2-3和對(duì)照組,按低、中、高劑量分別灌服2種濃香型白酒,連續(xù)灌胃8周,檢測(cè)大鼠肝功、血脂及脂肪分解、合成關(guān)鍵酶水平,對(duì)比組間差異。結(jié)果 AST水平1-3、2-1、2-2組較對(duì)照組有降低(P0.05);與對(duì)照組相比,1-2組ATGL升高(P0.05),且酒樣1的3個(gè)劑量組分別高于酒樣2的3個(gè)劑量組(P0.05);2-1、2-3組HSL升高(P0.05),且2-1組高于1-1組(P0.05);酒樣2的3個(gè)劑量組CPT-I水平均降低(P0.05),1-1、1-2組分別高于2-1、2-2組;酒樣組的ACO水平和DCAT水平較對(duì)照組分別升高(P0.05)和降低(P0.05);2-2組FAS水平低于對(duì)照組(P0.05)。結(jié)論適量濃香型白酒可提高部分脂肪分解關(guān)鍵酶水平,同時(shí)降低脂肪合成關(guān)鍵酶水平,這可能是適量飲酒對(duì)機(jī)體脂代謝調(diào)節(jié)的機(jī)制之一,這種調(diào)節(jié)作用可能與飲酒品質(zhì)相關(guān)。
[Abstract]:Objective to observe the effects of two kinds of Luzhou-flavor liquor on blood lipids and key enzymes of lipid metabolism in rats, and to analyze the difference of the effects of different liquor samples on lipid metabolism. Methods 105 male Sprague-Dawley rats were randomly divided into 7 groups: 1-1D 1-2N 1-3O2-1O2-2O2-3 and control group. Two kinds of Luzhou-flavor liquor were administered at low, medium and high doses respectively for 8 weeks. Liver function, lipids, lipid decomposition and synthesis of key enzymes were measured in rats. Results compared with the control group, the level of AST in groups 1-3 and 2-1 was lower than that in the control group (P 0.05), and the levels of ATGL in group 1 and 2 were higher than those in group 1, and the levels of HSL in group 2 were higher than those in group 2 (P 0.05) and higher than that in group 1 (P < 0.01). The levels of CPT-I in the three dosage groups of alcohol sample 2 were significantly lower than those in the control group (P 0.05) and the control group (P < 0.05), and the levels of CPT-I in the two groups were significantly higher than those in the control group (P < 0.05). Compared with the control group, the levels of ACO and DCAT in the liquor sample group were higher than those in the control group (P 0.05) and the level of FAS in the control group was lower than that in the control group. Conclusion moderate amount of Luzhou-flavor liquor can increase the level of some key lipolytic enzymes and decrease the level of fat synthesis key enzymes. This may be one of the mechanisms of moderate alcohol consumption regulating lipid metabolism, which may be related to drinking quality.
【作者單位】： 四川大學(xué)華西公共衛(wèi)生學(xué)院(華西第四醫(yī)院);重慶市渝中區(qū)疾病預(yù)防控制中心;四川省釀酒研究所;
【基金】：四川省科技廳資助項(xiàng)目(編號(hào):2014JY0216)
【分類號(hào)】：R-332

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