本文關鍵詞： 香鱗毛蕨有效部位乳膏 體內抗真菌活性 糠秕馬拉色菌 豚鼠模型　出處：《中國實驗方劑學雜志》2017年04期 　論文類型：期刊論文

【摘要】：目的:評價香鱗毛蕨有效部位乳膏(DF乳膏)對糠秕馬拉色菌所致豚鼠感染模型的治療作用。方法:構建糠秕馬拉色菌豚鼠皮膚感染模型,按皮損評分值隨機分成模型組,酮康唑組(1.33 mg·g-1),DF乳膏高、中、低劑量組(含生藥2,1,0.5 g·g-1),通過測定肉眼評分、菌落計數(CFU),真菌學轉陰率及組織病理檢查4項指標,評價DF乳膏對糠秕馬拉色菌所致豚鼠感染模型的治療作用。結果:與模型組比較,DF乳膏高、中、低劑量組均可顯著降低糠秕馬拉色菌所致感染模型豚鼠皮損評分(P0.05),明顯減少病變皮膚菌落形成數(P0.05),提高真菌培養(yǎng)的轉陰率(P0.05,P0.01);皮膚病理切片結果表明DF乳膏高、中劑量可明顯減少感染組織皮膚角質層孢子數。結論:DF乳膏對糠秕馬拉色菌所致的豚鼠感染有較好的治療作用。
[Abstract]:Objective: to evaluate the therapeutic effect of extract DF cream of Dryopteris furfurum on guinea pig infected with Malassezia furfurum. Methods: the skin infection model of Malassezia furfurum in guinea pigs was established. According to the score of skin lesion, ketoconazole group was randomly divided into three groups: the ketoconazole group was 1.33 mg 路g-1D ointment with high, middle and low doses (containing 21g 路g ~ (-1)) crude drug. Four indexes including gross score, colony count, mycological negative rate and histopathological examination were measured. To evaluate the therapeutic effect of DF cream on guinea pig infection induced by Malassezia furfurum. Results: compared with the model group, DF cream was higher and higher than that of the model group. The low dose group could significantly reduce the skin lesion score of guinea pigs induced by Malassezia furfurum (P0.05), and significantly reduce the number of diseased skin colony formation (P0.05). To increase the negative rate of fungi culture. The results of pathological section of skin showed that DF cream was high and medium dose could obviously reduce the number of spores in the cuticle of infected tissues. Conclusion the solution of 10% DF cream has a better therapeutic effect on the infection caused by Malassezia furfurum in guinea pigs.
【作者單位】： 廣東藥科大學中藥學院實驗動物中心;
【基金】：國家中醫(yī)藥管理局公益性行業(yè)科研專項(201507004) 國家“重大新藥創(chuàng)制”科技重大專項(2011ZX09102-007-03) 廣東省科技計劃項目(2015B020234009) 廣東省公益研究與能力建設專項資金項目(2015A030302088)
【分類號】：R275;R-332
【正文快照】： [網絡出版地址]http://www.cnki.net/kcms/detail/11.3495.R.20161129.1058.018.html[網絡出版時間]2016-11-29 10:58糠秕馬拉色菌Malassezia furfur,屬于馬拉色菌屬中常見的皮膚寄生菌致病菌。從馬拉色菌屬所致的各類型疾病中均能分離出M.furfur[1],該菌主要分布于人的頭皮、

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