本文關(guān)鍵詞： 翻譯起始 真核翻譯起始因子A 癌癥 纖維化 鉑類藥物化療　出處：《中南大學(xué)學(xué)報(醫(yī)學(xué)版)》2017年10期 　論文類型：期刊論文

【摘要】：真核生物翻譯控制在細胞進程中對基因表達調(diào)控具有重要作用,能確保蛋白的迅速調(diào)節(jié)以維持細胞內(nèi)穩(wěn)態(tài)。真核翻譯是一個多步驟的過程,包括起始、延伸、終止和核糖體循環(huán),其中起始是限速步驟,受真核翻譯起始因子(eukaryotic translation initiation factors,eIFs)調(diào)控。翻譯起始缺陷將導(dǎo)致一系列疾病。在所有eIFs中,eIF3是最大的同時知之較少的因子。eIF3A是eIF3因子的最大亞基,其異常一方面會導(dǎo)致腫瘤發(fā)生,另一方面將阻止腫瘤向更高級別惡性腫瘤進展。eIF3A表達變化和突變影響腫瘤患者對鉑類化療藥物的反應(yīng)。此外,eIF3A與纖維化病變相關(guān),抑制eIF3A的試劑能延緩病變進展。eIF3A在腫瘤中的雙重作用可能是其在腫瘤進展的不同階段調(diào)節(jié)不同mRNAs翻譯的結(jié)果,特定階段不同mRNAs的編碼產(chǎn)物發(fā)揮促癌或抑癌作用。
[Abstract]:Eukaryotic translation control plays an important role in the regulation of gene expression in the cell process, which ensures the rapid regulation of proteins to maintain the intracellular homeostasis. Eukaryotic translation is a multi-step process, including initiation and extension. Termination and ribosomal cycling, where the start is a rate-limiting step. Eukaryotic translation initiation factors. Among all eIFs, eIF3 is the largest and least known factor. EIF3A is the largest subunit of eIF3 factor. On the one hand, it will lead to tumorigenesis, on the other hand, it will prevent tumor progression to higher grade malignant tumor. The change of eIF3A expression and mutation will affect the reaction of tumor patients to platinum chemotherapy drugs. EIF3A was associated with fibrosis. The dual role of eIF3A in tumor may be due to its regulation of mRNAs translation at different stages of tumor progression. The encoding products of different mRNAs play the role of promoting or inhibiting cancer at certain stage.
【作者單位】： 中南大學(xué)湘雅醫(yī)院臨床藥理研究所;中南大學(xué)臨床藥理研究所湖南省遺傳藥理學(xué)重點實驗室;
【基金】：supported by the National Key Research and Development Plan(SQ2016YFSF110100,2016YFC0905000) National Natural Science Foundation(81373490,81573508,81573463) Hunan Provincial Science and Technology Plan(2015JC3025) Open Foundation of Innovative Platform in University of Hunan Province(421530004),China
【分類號】：R363
【正文快照】： The control of mRNA translation into protein is anelaborate process during gene expression regulation[1],which is critical for maintaining correct protein spatialdeployment and enabling rapid changes of intracellularproteins in response to external stimu，

本文編號：1458631