本文關(guān)鍵詞： 假結(jié)核耶爾森氏菌 侵襲素 整合素 黏附素 Ⅲ型分泌系統(tǒng) 電子斷層掃描技術(shù)　出處：《微生物學(xué)通報(bào)》2016年03期 　論文類型：期刊論文

【摘要】：耶爾森氏菌屬中有3個(gè)種對(duì)人和動(dòng)物具有致病性,包括鼠疫桿菌(Yersinia pestis)、小腸結(jié)腸炎耶爾森氏菌(Yersinia enterocolitica)和假結(jié)核耶爾森氏菌(Yersinia pseudotuberculosis)。研究發(fā)現(xiàn),假結(jié)核耶爾森氏菌能通過(guò)小鼠小腸派氏淋巴結(jié)的M細(xì)胞(Microfold cell)進(jìn)行跨細(xì)胞轉(zhuǎn)運(yùn)。這種轉(zhuǎn)運(yùn)方式首先是細(xì)菌利用其表面蛋白侵襲素Invasin或黏附素Yad A蛋白識(shí)別并結(jié)合宿主細(xì)胞表面的整合素Integrin受體家族成員的β1鏈,然后細(xì)胞膜上的分泌通道打開(kāi),細(xì)菌利用Ⅲ型分泌系統(tǒng)把效應(yīng)蛋白注入宿主細(xì)胞內(nèi),破壞宿主細(xì)胞免疫系統(tǒng)進(jìn)行感染的過(guò)程。過(guò)去三十年內(nèi)關(guān)于假結(jié)核耶爾森氏菌有大量的文獻(xiàn)報(bào)道,本文綜述該菌與宿主細(xì)胞之間相互作用分子機(jī)制的研究進(jìn)展,并討論目前關(guān)于假結(jié)核耶爾森氏菌的研究方向及熱點(diǎn)。
[Abstract]:Three species of Yersinia are pathogenic to humans and animals, including Yersinia pestis. Yersinia enterocolitica and Yersinia pseudotuberculosis. Yersinia pseudotuberculosis. Yersinia pseudotuberculosis can pass through M cells in the small intestinal lymph nodes of mice to microfold cells. Transcellular transport. This mode of transport is first used by bacteria using their surface protein Invasin or adhesin Yad. A protein recognizes and binds to the 尾 1 chain of integrin Integrin receptor family members on the surface of host cells. Then the secretory channel on the cell membrane was opened, and the bacteria injected the effector protein into the host cell by using the type 鈪，

本文編號(hào)：1450473