本文關(guān)鍵詞：白蝕丸聯(lián)合中波高能紫外線照射對(duì)白癜風(fēng)模型豚鼠血清補(bǔ)體及自身抗體水平的影響　出處：《中醫(yī)學(xué)報(bào)》2016年10期 　論文類型：期刊論文

  更多相關(guān)文章： 白蝕丸 中波高能紫外線照射 白癜風(fēng) 補(bǔ)體C 免疫球蛋白G 免疫球蛋白M 干擾素-γ 豚鼠 中藥

【摘要】：目的:觀察白蝕丸聯(lián)合中波高能紫外線照射對(duì)白癜風(fēng)模型豚鼠血清補(bǔ)體及自身抗體水平的影響。方法:將60只豚鼠分為正常對(duì)照組、模型對(duì)照組、白蝕丸組、中波高能紫外線照射組和白蝕丸聯(lián)合中波高能紫外線照射組,每組豚鼠12只。正常對(duì)照組正常飼養(yǎng),其余各組采用化學(xué)脫色法以建立白癜風(fēng)的動(dòng)物模型,于豚鼠皮膚涂抹體積分?jǐn)?shù)5%H_2O_21m L,每次2~3 min,每日2次,至豚鼠毛色變白,皮膚蒼白為造模成功。造模完成后,白蝕丸組以及白蝕丸聯(lián)合中波高能紫外線照射組給予白蝕丸2.0 g·kg~(-1),每日給藥1次,連續(xù)用藥30 d;中波高能紫外線照射組和白蝕丸聯(lián)合中波高能紫外線照射組采用UVB治療儀燈給予中波高能紫外線照射。比較各組皮膚色素恢復(fù)情況、豚鼠血清補(bǔ)體及自身抗體水平。結(jié)果:實(shí)驗(yàn)結(jié)束后,與正常對(duì)照組相比,其余各組色素恢復(fù)情況評(píng)分較低(P0.05);與模型對(duì)照組相比,其余各組色素恢復(fù)情況評(píng)分較高(P0.05);與白蝕丸組以及中波高能紫外線照射組相比,白蝕丸聯(lián)合中波高能紫外線照射組評(píng)分較高(P0.05)。與正常對(duì)照組相比,其余各組補(bǔ)體C3、IgG以及IgM較高(P0.05),干擾素-γ較低(P0.05);與模型對(duì)照組相比,其余各組補(bǔ)體C3、IgG以及IgM較低(P0.05),干擾素-γ較高(P0.05);與白蝕丸組以及中波高能紫外線照射組相比,白蝕丸聯(lián)合中波高能紫外線照射組補(bǔ)體C3、IgG以及IgM較低(P0.05),干擾素-γ較高(P0.05)。結(jié)論:白蝕丸聯(lián)合中波高能紫外線照射對(duì)白癜風(fēng)模型豚鼠皮膚色素具有良好的修復(fù)作用,下調(diào)血清IgG、IgM抗體以及補(bǔ)體C3水平,上調(diào)干擾素-γ,改善白癜風(fēng)對(duì)黑素細(xì)胞的破壞作用,抑制機(jī)體炎癥反應(yīng)。
[Abstract]:Objective: to observe the effect of white corrosion pill combined with high energy ultraviolet irradiation on serum complement and autoantibody levels in guinea pigs with vitiligo. Methods: 60 guinea pigs were divided into normal control group, model control group and white corrosion pill group. The animal model of vitiligo was established by chemical decolorization in each group with 12 guinea pigs in each group. At the volume fraction of 5H _ 2O _ 2 ~ 21ml, 2min twice a day, until the coat color of guinea pig turned white and the skin turned pale, the model was made successfully. The white corrosion pill group and the medium wave high energy ultraviolet radiation group were given the white corrosion pill 2.0 g 路kg ~ (-1) 路kg ~ (-1), once a day for 30 days. Medium wave high energy ultraviolet irradiation group and white corrosion pill combined with medium wave high energy ultraviolet radiation group were treated with UVB therapeutic instrument lamp. The recovery of skin pigment in each group was compared. Results: at the end of the experiment, compared with the normal control group, the recovery of pigments in the other groups was lower than that in the control group (P 0.05). Compared with the model control group, the pigment recovery score of the other groups was higher than that of the model control group (P 0.05). Compared with the white corrosion pill group and the medium wave high energy ultraviolet radiation group, the white corrosion pill combined with medium wave high energy ultraviolet radiation group had a higher score (P 0.05). Compared with the normal control group, the complement C3 in the other groups was higher than that in the other groups. IgG and IgM were higher (P 0.05) and interferon-緯 (IFN- 緯) was lower (P 0.05). Compared with the model control group, the levels of complement C _ 3G and IgM in the other groups were lower than that of the control group (P 0.05), and the levels of interferon-緯 were higher than that of the control group (P 0.05). Compared with the white corrosion pill group and the medium wave high energy ultraviolet radiation group, the complement C _ (3) G and IgM of the white corrosion pill combined with the medium wave high energy ultraviolet radiation group were lower than that of the other two groups (P _ (0.05)). Conclusion: Baiyongwan combined with high energy ultraviolet irradiation has a good effect on repairing skin pigments in guinea pigs with vitiligo and down-regulates serum IgG. The levels of IgM antibody and complement C3 upregulated interferon-緯, improved the destruction of melanocytes caused by vitiligo, and inhibited the inflammatory response of the body.
【作者單位】： 河北醫(yī)科大學(xué)第四醫(yī)院;中國(guó)人民解放軍白求恩國(guó)際和平醫(yī)院;邢臺(tái)市人民醫(yī)院;
【基金】：河北省醫(yī)學(xué)科學(xué)研究重點(diǎn)課題(20130252)
【分類號(hào)】：R285.5;R-332
【正文快照】： 文獻(xiàn)引用:胡彩霞,張國(guó)強(qiáng),馮佳.白蝕丸聯(lián)合中波高能紫外線照射對(duì)白癜風(fēng)模型豚鼠血清補(bǔ)體及自身抗體水平的影響[J].中醫(yī)學(xué)報(bào),2016,31(10):1537-1541.白癜風(fēng)是一種由于后天性限局性或者泛發(fā)性皮膚色素脫失導(dǎo)致的皮膚疾病[1],患者出現(xiàn)色素脫失斑,常為乳白色或淺粉色,本病常見于手

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