本文關鍵詞：西醫(yī)常規(guī)治療基礎上中藥保留灌腸治療肝性腦病療效的Meta分析，，由筆耕文化傳播整理發(fā)布。

西醫(yī)常規(guī)治療基礎上中藥保留灌腸治療肝性腦病療效的Meta分析

Clinical Efficacy of Western Conventional Treatment Based on Traditional Chinese Medicine Retention Enema on Hepatic Encephalopathy：A Meta-analysis

[1] [2] [3] [4]

LI Wen-wen, MENG Fan-jie, JIN Ying-hui, ZHOU Qian-mei （Graduate School of Tianjin University of Traditional Chinese Medicine, Tianfin 300073, P. R. China）

天津中醫(yī)藥大學研究生院,天津300073

文章摘要：目的評價西醫(yī)常規(guī)治療基礎上中藥保留灌腸治療肝性腦病的療效。方法計算機檢索Cochrane圖書館、Pub Med、EMbase、維普、中國知網(wǎng)、中國生物醫(yī)學文獻數(shù)據(jù)庫和萬方數(shù)據(jù)庫中關于西醫(yī)常規(guī)治療基礎上中藥保留灌腸（試驗組）對比西醫(yī)常規(guī)治療（對照組）治療肝性腦病的隨機對照試驗（RCT）,并追溯納入文獻的參考文獻,檢索時限為各數(shù)據(jù)庫從建庫至2013年11月。由2名研究者按照文獻納入和排除標準獨立進行文獻篩選、資料提取、質量評價并交叉核對后,采用Rev Man 5.1軟件進行Meta分析。結果最終納入26個RCT,共計1 691例患者。根據(jù)干預時間的長短進行亞組分析,7 d為1個療程。Meta分析結果顯示：干預時間≤1個療程,試驗組的總有效率高于對照組,兩組差異有統(tǒng)計學意義[RR=1.34,95%CI（1.25,1.44）,P〈0.000 01];干預時間〉1個療程,試驗組的總有效率高于對照組,兩組差異有統(tǒng)計學意義[RR=1.34,95%CI（1.21,1.48）,P〈0.000 01]。結論西醫(yī)常規(guī)治療基礎上中藥保留灌腸對于治療肝性腦病有顯著療效。由于納入分析的研究質量差異較大,因此有必要進行大樣本、多中心、隨機、雙盲的對照試驗,以進一步證實其臨床療效。

Abstr：Objective To evaluate the efficacy of western conventional treatment based on traditional Chinese medicine retention enema on patients with hepatic encephalopathy.Methods Such databases as the Cochrane Library,PubMed,EMbase,VIP,CNKI,CBM and WanFang Database were searched from the inception to November 2013 to collect randomized controlled trials（RCTs） about Western conventional treatment based on traditional Chinese medicine retention enema to treat hepatic encephalopathy,and the references of the included literature were also retrieved.Two reviewers independently screened the literature according to the inclusion and exclusion criteria,extracted the data,and evaluated and cross-checked the methodological quality.Then meta-analysis was conducted using RevMan 5.1 software.Results A total of 26 RCTs involving 1 691 patients were included.The subgroup analyses based on the length of intervention time showed that when the course of treatment intervention was less than one,the overall effective rate of the Chinese herbal retention enema group was higher than that of the control group,with a significant difference[RR=134,95%CI（1.25,1.44）,P〈0.000 01];after more than one course of treatment intervention,the overall effective rate of the Chinese herbal retention enema group was higher than that of the control group,with a significant difference[RR=134,95%CI（1.21,1.48）,P〈0.000 01].Conclusions On the basis of available evidence,the western medicine treatment based on traditional Chinese medicine retention enema for hepatic encephalopathy has a certain effect.However,the heterogeneity among the included studies is large.It is necessary to design multicenter,strictly randomized and doubleblind test controlled trials with large samples to validate these conclu

文章關鍵詞：

Keyword：:Traditional Chinese medicine enema Hepatic encephalopathy Meta-analysis

  本文關鍵詞：西醫(yī)常規(guī)治療基礎上中藥保留灌腸治療肝性腦病療效的Meta分析，由筆耕文化傳播整理發(fā)布。