本文選題：慢性心力衰竭 + 高血壓病　； 參考：《湖北中醫(yī)藥大學(xué)學(xué)報(bào)》2018年02期

【摘要】：目的觀察心衰1號(hào)方對(duì)高血壓病、糖尿病、冠心病并發(fā)慢性心衰(陽虛水停、血瘀絡(luò)阻證)患者的臨床療效。方法將我院120例患者分成治療組和對(duì)照組,每組各60例。治療組給予西醫(yī)常規(guī)治療聯(lián)合心衰1號(hào)方治療,對(duì)照組給予西醫(yī)常規(guī)治療聯(lián)合芪藶強(qiáng)心膠囊治療,療程均為4周。比較兩組間紐約心臟病協(xié)會(huì)(NYHA)心功能分級(jí)、中醫(yī)證候積分、心衰體征積分、左室射血分?jǐn)?shù)(LVEF)、B型腦鈉肽(BNP)、生活質(zhì)量評(píng)價(jià)、住院時(shí)間及不良反應(yīng)發(fā)生率。結(jié)果對(duì)照組總有效率(73.33%)低于治療組(88.33%),差異有統(tǒng)計(jì)學(xué)意義(P0.05);與對(duì)照組比較,治療組治療后中醫(yī)證候積分、心衰體征積分較低,BNP水平較低,生活質(zhì)量評(píng)分較低,住院時(shí)間較短,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。治療后,兩組LVEF均有明顯的改善(P0.05),改善程度差異無統(tǒng)計(jì)學(xué)意義(P0.05)。兩組不良反應(yīng)發(fā)生率差異無統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論心衰1號(hào)方治療高血壓病、糖尿病、冠心病并發(fā)慢性心衰(陽虛水停、血瘀絡(luò)阻證)的臨床療效較好,能夠有效改善患者心功能,改善患者臨床癥狀及生活質(zhì)量,降低BNP水平,升高左室射血分?jǐn)?shù)(LVEF)水平,安全性良好。
[Abstract]:Objective to observe the clinical effect of Heart failure Formula No. 1 on patients with hypertension, diabetes and coronary heart disease complicated with chronic heart failure (Yang deficiency and water stagnation, blood stasis and collaterals obstruction). Methods 120 patients in our hospital were divided into treatment group and control group with 60 cases in each group. The treatment group was treated with routine western medicine combined with heart failure recipe No. 1, the control group was treated with traditional western medicine combined with Qiliqiangxin capsule, the course of treatment was 4 weeks. The cardiac function grading, TCM syndromes score, heart failure sign score, left ventricular ejection fraction (LVEF) B type brain natriuretic peptide (BNPP), quality of life (QOL), hospital stay and incidence of adverse reactions were compared between the two groups. Results the total effective rate of the control group (73.33) was lower than that of the treatment group (88.33%), and the difference was statistically significant (P 0.05), compared with the control group, the scores of TCM syndromes, signs of heart failure and BNP were lower, the quality of life score was lower, and the hospitalization time was shorter in the treatment group than in the control group. The difference was statistically significant (P 0.05). After treatment, LVEF in both groups was significantly improved (P 0.05), and there was no significant difference in the degree of improvement between the two groups (P 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P 0.05). Conclusion the clinical effect of Heart failure No. 1 prescription in treating hypertension, diabetes mellitus and coronary heart disease complicated with chronic heart failure (Yang deficiency and water stopping, blood stasis and collaterals blocking) is better. It can effectively improve the heart function of the patients, improve the clinical symptoms and quality of life of the patients. It is safe to reduce BNP level and increase left ventricular ejection fraction (LVEF) level.
【作者單位】： 中國(guó)中醫(yī)科學(xué)院廣安門醫(yī)院南區(qū)內(nèi)科
【基金】：北京市中醫(yī)藥科技發(fā)展資金項(xiàng)目(項(xiàng)目編號(hào):JJ2012-01)
【分類號(hào)】：R259

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