本文選題：多囊卵巢綜合征 + 痰濕證�。� 參考：《黑龍江中醫(yī)藥大學(xué)》2017年碩士論文

【摘要】：目的:本研究通過對(duì)270例多囊卵巢綜合征痰濕證患者和62例健康女性的一般臨床特征及生化指標(biāo)進(jìn)行分析,探討PCOS痰濕證伴高雄激素血癥患者的臨床特征,以期為疾病的個(gè)性化診治及遠(yuǎn)期并發(fā)癥的預(yù)防提供依據(jù)。方法:收集2014年12月至2017年2月黑龍江中醫(yī)藥大學(xué)附屬第一醫(yī)院臨床科研信息一體化系統(tǒng)中270例PCOS痰濕證患者,根據(jù)T及AND水平將PCOS痰濕證患者分為痰濕證PCOS+HA組、痰濕證PCOS+non-HA組,選擇同期就診于本院體檢中心的健康女性62例作為對(duì)照組。采集并記錄三組受試者的一般臨床信息、性腺激素、雄激素、糖脂等實(shí)驗(yàn)室指標(biāo),運(yùn)用SPSS19.0統(tǒng)計(jì)軟件進(jìn)行分析。結(jié)果:(1)與對(duì)照組比較,痰濕證PCOS+HA組和痰濕證PCOS+non-HA組的初潮年齡、WC、DBP,痤瘡、黑棘皮、溢脂及多毛的發(fā)生率顯著增高,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。痰濕證PCOS+HA組的多毛發(fā)生率顯著高于痰濕證PCOS+non-HA組,痰濕證PCOS+HA的體重顯著高于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。三組年齡、BMI、身高、WHR、SBP差異無統(tǒng)計(jì)學(xué)意義(P0.05),但三組均表現(xiàn)為肥胖,且為腹型肥胖;(2)與對(duì)照組比較,痰濕證PCOS+HA組的FSH顯著降低而DHEAS顯著升高;痰濕證PCOS+non-HA 組的 FSH、SHBG 顯著降低,DHEAS、LH、LH/FSH 值顯著升高,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。痰濕證PCOS+HA組的LH、LH/FSH、AND及T值顯著高于痰濕證PCOS+non-HA組和對(duì)照組,SHBG水平顯著低于痰濕證PCOS+non-HA組和對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05);(3)與對(duì)照組相比,痰濕證PCOS+non-HA組的TG、LDL、APOB及APOB/APOA值顯著升高,痰濕證PCOS+HA組的APOB及APOB/APOA顯著高,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。痰濕證PCOS+HA組的TC、TG、LDL值顯著高于痰濕證PCOS+non-HA組和對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。三組HDL及APOA差異無統(tǒng)計(jì)學(xué)意義(P0.05);(4)痰濕證PCOS+HA組的FPG、FINS、HOMA-IR值均顯著高于痰濕證PCOS+non-HA組及對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。與對(duì)照組比較,痰濕證PCOS+non-HA組的FINS和HOMA-IR值顯著升高,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:(1)多囊卵巢綜合征痰濕證合并HA患者多毛發(fā)生率較高;(2)多囊卵巢綜合征痰濕證合并HA患者性激素代謝異常較重;(3)多囊卵巢綜合征痰濕證合并HA患者糖脂代謝紊亂較重。
[Abstract]:Objective: to study the clinical features and biochemical indexes of 270 patients with phlegm dampness syndrome and 62 healthy women with PCOS phlegm dampness syndrome and hyperandrogenemia. In order to provide basis for individualized diagnosis and treatment of disease and prevention of long-term complications. Methods: 270 PCOS patients with phlegm dampness syndrome were collected from December 2014 to February 2017 in the first affiliated Hospital of Heilongjiang University of traditional Chinese Medicine. According to the levels of T and, PCOS patients with phlegm dampness syndrome were divided into phlegm dampness syndrome PCOS HA group. Patients with phlegm dampness syndrome PCOS non-HA group were selected as control group. The clinical data of the three groups were collected and recorded. The laboratory indexes of gonadal hormone androgen sugar and lipid were analyzed by SPSS 19.0 software. Results compared with the control group, the incidence of menarche age in phlegm dampness syndrome PCOS HA group and phlegm dampness PCOS non-HA group was significantly higher than that in control group (P 0.05). The incidence of hirsutism in phlegm dampness syndrome PCOS HA group was significantly higher than that in phlegm dampness syndrome PCOS non-HA group, and the weight of phlegm dampness syndrome PCOS HA group was significantly higher than that of control group (P 0.05). There was no significant difference in BMIand WHRS-SBP among the three groups, but all of the three groups were obese, and were abdominal obesity.) compared with the control group, the FSH of the phlegm-dampness syndrome PCOS HA group was significantly lower and the DHEAS significantly higher than that of the control group. In PCOS non-HA group of phlegm-dampness syndrome, the SHBG of FSHS significantly decreased and the value of LHH / FSH in DHEASA was significantly higher than that in PCOS non-HA group, and the difference was statistically significant (P 0.05). The levels of LHH / FSHAND and T in phlegm dampness syndrome PCOS group were significantly higher than those in phlegm dampness syndrome PCOS non-HA group and control group. The levels of SHBG in phlegm dampness syndrome PCOS non-HA group and control group were significantly lower than those in phlegm dampness syndrome PCOS non-HA group and control group. The APOB and APOB / APOA of PCOS HA group with phlegm dampness syndrome were significantly higher than those of PCOS HA group (P 0.05). Compared with non-HA group and control group in phlegm-dampness syndrome PCOS group, the TCU TGN LDL value in PCOS HA group was significantly higher than that in PCOS non-HA group and control group in phlegm-dampness syndrome group, the difference was statistically significant (P 0.05). There was no significant difference in HDL and APOA among the three groups (P 0.05). The FINSHOMA-IR of phlegm dampness syndrome PCOS HA group was significantly higher than that of phlegm dampness syndrome PCOS non-HA group and control group (P 0.05). Compared with control group, fins and HOMA-IR in PCOS non-HA group of phlegm-dampness syndrome were significantly higher than those in control group (P 0.05). Conclusion (1) the incidence of polytrichoresis in patients with phlegm dampness syndrome combined with HA is higher than that in patients with polycystic ovary syndrome. (2) abnormal sex hormone metabolism in patients with phlegm dampness syndrome combined with HA is more serious than that in patients with polycystic ovary syndrome (PCOS) phlegm dampness syndrome with HA is more serious in the disorder of glucose and lipid metabolism in patients with polycystic ovary syndrome.
【學(xué)位授予單位】：黑龍江中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R271.9

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