本文選題：子宮內(nèi)膜異位癥 + 左歸丸　； 參考：《新疆醫(yī)科大學》2017年碩士論文

【摘要】：目的:觀察左歸丸對子宮內(nèi)膜異位癥術(shù)后的患者應用GnRH-a所致副作用的治療情況及患者生存質(zhì)量的影響。方法:所有入組的患者術(shù)后給予國產(chǎn)醋酸亮丙瑞林微球3.75mg一針,每隔4周注射一次,共3針,在第一針治療后出現(xiàn)潮熱汗出、失眠等副作用的腎陰虛型患者,隨機分成對照組及試驗組。對照組30例,在第二針時反向添加戊酸雌二醇1mg/d及醋酸甲羥孕酮2mg/d。試驗組30例,在對照組的基礎(chǔ)上口服左歸丸每日2次。觀察Kupperman評分、EHP-5中文版的評分量表,監(jiān)測雌二醇情況。結(jié)果:使用一針后兩組E2水平均處于低雌激素水平,兩組比較差異無統(tǒng)計學意義(P0.05),使用3針時兩組E2水平比較差異無統(tǒng)計學意義(P0.05)。改良Kupperman評分:(1)試驗組和對照組的患者治療4周后,兩組的評分與術(shù)前相比較,差異有統(tǒng)計學意義(P0.05)。兩組治療12周與治療4周前后比較差異有統(tǒng)計學意義(P0.05)。(2)治療12周時兩組比較差異有統(tǒng)計學意義(P0.05)。治療4周及停藥3月后兩組評分比較無差異(P0.05)。EHP-5評分:(1)兩組治療12周與治療4周前后比較,差異有統(tǒng)計學意義(P0.05)。(2)治療12周時兩組在癥狀影響生活、自我印象、性生活情況方面比較差異有統(tǒng)計學意義(P0.05)。(3)停藥后3月試驗組和對照組兩組比較差異無統(tǒng)計學意義(P0.05)。結(jié)論:(1)使用左歸丸是安全有效的。(2)內(nèi)異癥術(shù)后的患者使用GnRH-a時,兼口服左歸丸可以明顯減輕GnRH-a的副作用。(3)左歸丸能夠提高患者的生存質(zhì)量,降低患者的負性心理,讓使用GnRH-a類藥物的患者適應此階段治療,提高患者的依從性。
[Abstract]:Aim: to observe the effect of Zuogui pill on the side effects of GnRH-a and the quality of life of patients with endometriosis after operation. Methods: all the patients in the group were treated with a single injection of 3.75mg every 4 weeks and 3 injections. After the first injection, the patients suffered from the side effects of hot flashes, sweating, insomnia and other side effects, such as deficiency of kidney yin. They were randomly divided into two groups: control group and experimental group. 30 patients in the control group were treated with estradiol valerate (1mg/d) and medroxyprogesterone acetate (2mg / d). The experimental group (30 cases) was treated with Zuo Gui pill twice a day on the basis of control group. To observe the Kupperman score and EHP-5 score scale in Chinese version, and monitor the status of estradiol. Results: the level of E _ 2 in the two groups was at low estrogen level after one injection. There was no significant difference between the two groups in E _ 2 level, but there was no significant difference in E _ 2 level between the two groups after the use of three needles. After 4 weeks of treatment, the scores of the two groups were significantly different from those before treatment (P 0.05). There was significant difference between the two groups before and after treatment at 12 weeks and 4 weeks after treatment (P 0.05. 05) at 12 weeks of treatment, there was a significant difference between the two groups (P 0. 05). There was no difference in the scores between the two groups after 4 weeks of treatment and 3 months after withdrawal. There was no significant difference between the two groups in terms of symptoms affecting life and self impression at 12 weeks after treatment compared with those before and after treatment for 12 weeks and before and after 4 weeks of treatment. There was no significant difference between the experimental group and the control group 3 months after the withdrawal of the drug, there was no significant difference between the two groups (P 0.05). Conclusion (1) it is safe and effective to use Zuogui Pill. (2) when patients with endometriosis are treated with GnRH-a, the side effects of GnRH-a can be significantly alleviated by taking Zuogui Pill.) Zuo Gui Pill can improve the quality of life of patients and reduce the negative psychology of the patients. Make patients with GnRH-a drugs adapt to this stage of treatment and improve compliance.
【學位授予單位】：新疆醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R713

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