本文選題：良性單純性甲狀腺結(jié)節(jié)　切入點：癭病　出處：《黑龍江中醫(yī)藥大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:探究柴夏牡蠣湯治療良性單純性甲狀腺結(jié)節(jié)患者甲狀腺結(jié)節(jié)的臨床療效,并驗證其安全性。方法:根據(jù)隨機數(shù)字表法,將符合納入標準的68例患者隨機分為兩組,柴夏牡蠣湯組和夏枯草顆粒組,每組34例,柴夏牡蠣湯組給予柴夏牡蠣湯,1劑/日,口服;夏枯草顆粒組給予夏枯草顆粒,1袋/次,2次/日,口服;同時配合基礎(chǔ)治療,共治療3個月,治療結(jié)束后觀察兩組患者的甲狀腺最大結(jié)節(jié)大小(直徑)、數(shù)目及中醫(yī)證候分級量化表的影響。利用SPSS17.0統(tǒng)計學(xué)軟件對數(shù)據(jù)結(jié)果進行處理和分析。結(jié)果:1.甲狀腺最大結(jié)節(jié)大小(直徑)方面:柴夏牡蠣湯組治療前后,有極顯著性差異(p0.01),夏枯草顆粒組治療后與治療前相比,有顯著性差異(P0.05);治療后柴夏牡蠣湯組與夏枯草顆粒組相比,有極顯著性差異(P0.01)。2.甲狀腺結(jié)節(jié)數(shù)目方面:柴夏牡蠣湯組治療前后,無顯著性差異(p0.05),夏枯草顆粒組治療后與治療前相比,無顯著性差異(p0.05);治療后柴夏牡蠣湯組與夏枯草顆粒組相比,無顯著性差異(p0.05)。3.在中醫(yī)癥候積分方面:柴夏牡蠣湯組治療前后,有極顯著性差異(p0.01),夏枯草顆粒組治療后與治療前相比,有極顯著性差異(P0.01);治療后柴夏牡蠣湯組與夏枯草顆粒組相比,有極顯著性差異(P0.01)。4.兩組患者治療前后甲狀腺功能檢查,無顯著性差異(p0.05),患者服藥后無惡心嘔吐,腹瀉,皮膚瘙癢等不良影響。結(jié)論1.柴夏牡蠣湯能縮小良性單純性甲狀腺結(jié)節(jié)患者的結(jié)節(jié)大小。2.柴夏牡蠣湯能顯著改善良性單純性甲狀腺結(jié)節(jié)患者的中醫(yī)證候。3.柴夏牡蠣湯不會引起患者的甲狀腺功能的變化,且安全性好。
[Abstract]:Objective: to investigate the clinical efficacy and safety of Chaixia Oyster soup in the treatment of thyroid nodules in benign simple thyroid nodules. Methods: according to the random digital table, 68 patients with benign thyroid nodules were randomly divided into two groups. In the Chaixia Oyster soup group and the Prunus subtilis granule group, 34 cases in each group, the Chaixia Oyster soup group was given 1 dose per day of Chaixia Oyster soup, and the Prunella subtilis granule group was given 1 bag / twice a day for oral use; at the same time, it was treated with basic treatment. For a total of 3 months, After the treatment, we observed the influence of the largest thyroid nodule size (diameters, numbers and TCM syndromes grading) in the two groups. The data were processed and analyzed by SPSS17.0 software. Results: 1. The thyroid gland was the largest. Nodule size (diameter): before and after treatment in the Chaixia Oyster soup group, There was a significant difference between the two groups after treatment (P 0.05), and after treatment, there was a significant difference between the two groups (P 0.05), and after the treatment, there was a significant difference between the two groups. There was significant difference in the number of thyroid nodules: there was no significant difference in the number of thyroid nodules before and after treatment in the Chaixia Oyster soup group, and there was no significant difference between the two groups before and after treatment (P 0.05), and there was no significant difference in the number of thyroid nodules between the two groups after treatment. After treatment, there was no significant difference between the Chaixia Oyster soup group and the Prunus subtilis granule group. There was no significant difference in the score of TCM symptoms: before and after treatment, there was no significant difference between the Chaixia Oyster soup group and the Prunus subtilis granule group. There was a significant difference between the two groups after treatment (P 0.01), after treatment, there was a significant difference between the two groups (P 0.01), and after treatment, there was a significant difference between the Chaixia Oyster soup group and the Prunella granulosa group (P 0.01). 4. Before and after treatment, the thyroid function of the patients in the two groups was examined, and compared with that before and after treatment, there was a significant difference between the two groups. There was no significant difference (P 0.05). There was no nausea, vomiting and diarrhea after taking medicine. Conclusion 1. Chai Xia Oyster soup can reduce the nodule size of benign simple thyroid nodule patients. 2. Chai Xia Oyster soup can significantly improve the TCM syndrome of benign simple thyroid nodule patients. 2. Chaixia Oyster soup can significantly improve the TCM syndrome of benign simple thyroid nodule patients. 3. Chaixia Oyster soup can reduce the nodule size of benign simple thyroid nodule patients. Oyster soup does not cause changes in the thyroid function of patients, And the safety is good.
【學(xué)位授予單位】：黑龍江中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R259

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